Inaug.-diss.--Frankfurt a. Main. / Lebenslauf. "Diese Arbeit erscheint gleichzeitig in den Forschungen zur deutschen Landes- und Volkskunde, Band XXX, Heft 3." "Literaturverzeichnis": p. [117]-125.

Thesis (M.S.)--University of Wisconsin--Madison, 1971. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

This thesis examines the doctrine of the incarnation with particular attention to the implications of this doctrine for a theological understanding of human/nonhuman relationships. To do so, it is guided by two driving questions: Why did God become human in particular in the incarnation?, and what are the implications of the humanity of Christ for the way in which Christian theology construes the human/nonhuman relationship? Each chapter is guided by these questions, and seeks to find and test the answers given by four major theologians from the Christian tradition: Anselm of Canterbury and sin, Gregory of Nyssa and the image of God, Maximus the Confessor and the human constitution as microcosm, and Karl Barth and the human calling to be a representative covenantal partner. Through the use of the guiding questions, and engagement with these four theologians and their respective answers, three theses are developed over the course of the dissertation. First, that God’s motivation for the incarnation extends beyond the human to include the nonhuman creature. Of the various reasons put forward throughout this thesis, each of them is shown to include the nonhuman animal in some way. Second, that God became human in particular due to the unique human calling to be a representative creature. In arriving at this conclusion, various viewpoints are considered and ultimately rejected as being sufficient to account for God’s will to become human in particular. Third, the unique human calling of representation is shown to carry with it ethical implications for humans with regards to nonhuman animals. Given the human calling of representing creation to God, and God to creation, there are necessary ethical implications which such a calling has for what it means to be human.

In this study the question of nonrandomness in the distribution of human constitutional rearrangements was evaluated. The distribution of breakpoints were analysed in three groups of reciprocal translocations and three groups of inversions, subdivided according to method of ascertainment of cases for study. In addition, one data set of structural aberrations obtained from sperm chromosomes was also analysed. The method of statistical analysis, based on the binomial distribution, was developed specifically to allow testing distributions in chromosome segments as small as chromosome bands. The distribution of breakpoints was analysed in all data sets using this method, in addition to testing for overall nonrandomness using goodness of fit statistics. Nonrandomness in breakpoint distributions was found in reciprocal translocations (rcp) and inversions ascertained through abnormalities and through incidental events. However, random distribution was observed in incidentally ascertained de novo rearrangements as well as in sperm chromosome aberrations. The nonrandomness in the distribution of rcp breakpoints can be largely attributed to a bias in ascertainment of cases based on the phenotypic manifestations of chromosomal imbalance resulting from a rearrangement. A dependence of the probability of producing specific types of balanced or unbalanced progeny on the position of breakpoints is a likely explanation for the nonrandomness produced in breakpoint distributions. However, some bands including, 5q35, 7p22, 9p22, 13ql4, and 17q25, were observed in different ascertainment groups, excluding selection bias as a likely explanation for this observation. These bands may represent true sites of nonrandom rearrangement due to some factor associated with an underlying DNA sequence or structural characteristic of chromatin that predisposes to rearrangement at specific sites. The nonrandomness observed in the distribution of inversion breakpoints is most likely the product of a founder effect. Many identical inversions in apparently unrelated individuals have been found suggesting that a few ancestral mutations have become widespread in the population. A large data set of incidentally ascertained de novo inversions is required to distinguish between sites of frequent breakage and nonrandomness produced by the ascertainment of related cases. All evidence considered together, indisputable predisposition to rearrangement at specific sites was not found in this study. Furthermore, an overall random association of constitutional rearrangement breakpoints in bands with known oncogenes and fragile sites was observed. However, the possibility of oncogenes and fragile sites as factors involved in constitutional rearrangements in a few isolated cases cannot be excluded. Nonrandomness was found when distribution of breakpoints in light and dark G bands was compared. An excess of breakpoints in some light G bands was observed even after a conservative correction for a possible pattern recognition bias which may lead to the overascertainment of breakpoints in light G bands. / Medicine, Faculty of / Medical Genetics, Department of / Graduate

Cameroon has been in the throes of a bloody conflict in the English-speaking regions since 2016. It is a conflict over political, cultural rights and identity and has deteriorated with government forces implicated in serious human rights violations such as extrajudicial and summary executions, torture, forced disappearances, arbitrary arrest and incommunicado detention, arson and destruction of villages. Separatist fighters have equally inflicted pain on civilians who do not support their agenda through kidnapping, maiming and targeted killings. Transitional justice (TJ) stands as a panacea to addressing the serious human rights violations resulting from conflicts. The AU through its different organs and institutions have developed mechanisms for the implementation of TJ. The AU Transitional Justice Policy (AUTJP) provides a roadmap for other institutions to assist member states to develop context-specific comprehensive policies, strategies, and programmes towards achieving peace, justice and reconciliation. The African Commission as a key institutions for implementing TJ incorporates TJ into its existing mechanisms which makes TJ centred responses weak. The study proposes several measures to improve on the Commissions response. It equally highlights the peculiarities and challenges at the level of the Cameroon and proposes measures to be adopted to achieve peace and justice. / Mini Dissertation (LLM (Human Rights and Democratisation in Africa))--University of Pretoria, 2021. / Centre for Human Rights / LLM (Human Rights and Democratisation in Africa) / Unrestricted

The pattern of inactivation in the DXS8237E-UBE1-PCTK1 region is of particular interest, since the mechanisms of X chromosome inactivation and the escape from inactivation are, as yet, not fully understood. The inactivation status of the DXS8237E and PCTKl gene differ: the first undergoes normal inactivation and the second escapes this process. The status of the UBEl gene has been controversial, although it is widely excepted that it does escape X chromosome inactivation. Physical mapping of the region employing YACs and subsequently P ACs has been undertaken, but was restricted in scope by the high frequency of rearrangements occurring. DNA sequences between DXS8237E, UBE1, PCTKl and the distal gene, UHX1, have been investigated with regard to LINEI elements, which are thought to playa role in X-inactivation. The results obtained strongly suggest a link between LINE1 elements and X chromosome inactivation. Sequence analysis results also contributed to the understanding of difficulties with restriction mapping of the region. Further, this work includes the first reported establishment of the UBEl exonintron boundaries. Additionally, genomic sequence analysis showed that only 46kb separate DXS8237E from UHX1, which confirms that this region is extremely gene rich.

Thesis (M.A.)--York University, 2001. / Typescript. Includes bibliographical references (leaves 257-270). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pMQ67717.

The pattern of inactivation in the DXS8237E-UBE1-PCTK1 region is of particular interest, since the mechanisms of X chromosome inactivation and the escape from inactivation are, as yet, not fully understood. The inactivation status of the DXS8237E and PCTKl gene differ: the first undergoes normal inactivation and the second escapes this process. The status of the UBEl gene has been controversial, although it is widely excepted that it does escape X chromosome inactivation. Physical mapping of the region employing YACs and subsequently P ACs has been undertaken, but was restricted in scope by the high frequency of rearrangements occurring. DNA sequences between DXS8237E, UBE1, PCTKl and the distal gene, UHX1, have been investigated with regard to LINEI elements, which are thought to playa role in X-inactivation. The results obtained strongly suggest a link between LINE1 elements and X chromosome inactivation. Sequence analysis results also contributed to the understanding of difficulties with restriction mapping of the region. Further, this work includes the first reported establishment of the UBEl exonintron boundaries. Additionally, genomic sequence analysis showed that only 46kb separate DXS8237E from UHX1, which confirms that this region is extremely gene rich.

Thesis (PhD) -- Australian Catholic University, 2006. / Submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy. Bibliography: p. 337-361. Also available in an electronic format via the internet.

Thesis (M.A. (Human Rights))--Mahidol University, 2006. / LICL has E-Thesis 0019 ; please contact computer services.