Objective To determine the cardiopulmonary and blood gas status of elephants during chemical capture (immobilisation) with a thiafentanil-azaperone drug combination kept in lateral recumbency. Study design Prospective descriptive study. Animal population Ten free-ranging adult African elephant bulls (estimated weight range 3000 to 6000 kg). Methods Elephants were immobilised using a thiafentanil (15-18 mg) and azaperone (75-90 mg) by darting from a helicopter. Once recumbent, the tidal volume, minute volume, end-tidal carbon dioxide, arterial blood pressure and pulse rate were recorded immediately after instrumentation and at five-minute intervals until T20. Arterial and venous blood gases were analysed at the time of initial instrumentation and at 20 minutes. On completion of the data collection, the thiafentanil was antagonised using naltrexone (10 mg mg-1 thiafentanil). A stopwatch was used to record time to recumbency (dart placement to recumbency) and time to recovery (administering antagonist to standing). Data was checked for normality and was found to be parametric. Data were compared using a one-way analysis of variance and reported as mean (± SD). Results All elephants were successfully immobilised and all physiological variables remained constant with minimal non-significant variation over time. Average time to recumbency was 12.5 minutes. The estimated expiratory tidal volume was 21 (± 6) L breath-1 or 4.8 ± 0.8 mL kg-1, and the measured minute volume was 103 (± 31) L minute-1. The heart and respiratory rates were 49 (±6) beats and 5 (± 1) breaths minute-1, respectively. The mean arterial blood pressure was 153 (± 31) mmHg. The elephants were acidaemic (pH 7.18 ±0.06; bicarbonate ion 20 ±4 mmol L-1; lactate 11 ± 4 mmol L-1), mildly hypoxemic (PaO2 68 ± 15 mmHg) and mildly hypercapnic (PaCO2 52 ± 7 mmHg). Average time to recovery was 2.2 minutes. Conclusion and clinical relevance African elephant bulls can be successfully immobilised using thiafentanil-azaperone. Recumbency was rapid, the cardiopulmonary variables were stable and within acceptable ranges, and recovery was rapid and complete. Mild hypoxaemia and hypercapnia were evident, but does not necessarily require oxygen supplementation. / Dissertation (MSc)--University of Pretoria, 2020. / Companion Animal Clinical Studies / MSc / Unrestricted