NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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1

The development, validation, and characterization of an ex-vivo porcine full thickness skin model for the study of the subcutaneous compartment

Jordanna Michelle Payne (15348601) 27 April 2023 (has links)
<p>This dissertation details the creation, validation, and characterization of a porcine ex-vivo culture model to study subcuteneous tissue. The viability of the model was assessed over seven days of culture by digestion and the proliferation and death of cells was monitored by immunohistochmeical labelling and image analysis. The model was then used in a timecourse proteomics experiment to characterize the effect of culture on subcutaneous proteome. The model was then compared to a commercially available human ex-vivo model with respect to viability and changes to the subcutaneous proteome. </p>
Biomedical imaging
Tissue engineering
subcutaneous tissue engineering
tissue engineering platforms
subcutaneous proteomics
ex vivo culture
ex vivo culture models
time course proteomics

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