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Success rate of tobacco dependence treatment among patients with and without a history of depression Introduction: Higher prevalence of smoking among depressive patients, as well as higher risk of depression in smokers, are well documented. Views on treatment of tobacco dependence in this subgroup of smokers are controversial. Aim: A/ To compare the abstinence rate among smokers with or without a history of depression receiving treatment for nicotine dependence at one year follow up. B/ Factors associated with treatment success were evaluated and analysed. Methods: A retrospective analysis of 1 730 smokers treated at our Centre for Tobacco-Dependent (CTD) between 2005 and 2010 was conducted. Patients were treated with a combination of psychobehavioural interventions and pharmacotherapy (nicotine replacement therapy, varenicline, bupropion or combinations). At one year follow-up smoking abstinence was biochemically validated by measuring expired CO. Results: 16.7 % (289/1730) of smokers currently, or had formerly, received treatment for depression. Based on the average Fagerström Test of Nicotine Dependence (FTND), most patients with a history of depression were heavily nicotine dependent with a score of 6.1, compared to 5.6 (p=0.010) among those without a history of depression. The CO validated success rate...

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