Thesis (M. Med. Sc.)--University of Hong Kong, 2004. / Also available in print.

Thesis (M. Med. Sc.)--University of Hong Kong, 2005. / Also available in print.

Thesis (M.S. in Management) Naval Postgraduate School, December 1993. / Thesis advisor(s): Evered, Roger ; Wargo, Linda Ellen. "December 1993." Includes bibliographical references. Also available online.

Dissertation--University of South Australia, 2008. / Includes bibliographical references (p. [237]-285).

Thesis, PlanB (M.S.)--University of Wisconsin--Stout, 2006. / Includes bibliographical references.

Thesis (Ed. Spec.)--University of Wisconsin--Stout, 2005. / Field study. Includes bibliographical references.

Thesis (M. Hous. M.)--University of Hong Kong, 2005.

Thèse--Méd.--Reims, 1973. N°: N° 3. / Bibliogr. ff. I-XI.

This thesis describes research towards the total syntheses of two bacterial polyene natural products, inthomycin C and oxazolomycin B, as well as preliminary studies on the biological activity of inthomycin C and structural analogues against human cancer cell lines. A novel total synthesis of inthomycin C has been accomplished in 11.4% yield and 89% ee over ten linear steps from oxazole. This synthesis is the shortest and highest yielding asymmetric total synthesis of inthomycin C to date and, unlike all previous syntheses, it avoids the use of toxic organotin reagents. Main features of this synthesis include cross-metathesis as key C - C bond-forming step, methoxy group elimination to construct the triene moiety and asymmetric Mukaiyama - Kiyooka aldol addition to install the (3R) alcohol stereocenter on inthomycin C. Both NMR data and optical rotation data for the sample of inthomycin C synthesised in this work are in agreement with those previously reported. Viability and cytotoxicity assays of inthomycin C and analogues against various human cancer cell lines have been carried out for the first time. Despite all compounds tested having proved inactive against all cancer cell lines, an ester derivative of inthomycin C has been found to exhibit weak reversible proteasome inhibition activity against two cancer cell lines. On the other hand, and building on previous work in the Donohoe group, the synthesis of an advanced amide intermediate in the route towards oxazolomycin B has been achieved, which contains the complete carbon backbone of oxazolomycin B. Key features of this synthesis include a highly diastereoselective organocerium nucleophilic addition to an aldehyde precursor, a Nozaki - Hiyama - Kishi reaction and an amide coupling to access the final amide fragment.

Organosilanes are widely used to bond organic materials such as polymers to inorganic materials in polymer composites. However, the mechanism of adhesion is poorly understood. One postulated mechanism is the interdiffusion of the silane and polymer, along with condensation of the silane to form an interpenetrating polymer network (IPN). The techniques of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and Raman confocal microscopy have been used to study the diffusion, hydrolysis and condensation of three organosilanes in silicon / PVC / silane laminates. These processes are thought to contribute to the formation of the IPN, and hence to be vital for adhesion. The organosilanes studied were [3-(amino)propyl]trimethoxysilane, also known as A1110, [3-(phenylamino)propyl]trimethoxysilane, known as Y9669, and [3-(mercapto)propyl]triethoxysilane, known as A1891.ATR-FTIR was shown to be an excellent technique for studying the kinetics of silane diffusion through PVC films. It was shown that at room temperature, no diffusion through unplasticised PVC films occurred. At 70 °C, however, diffusion occurred readily for Y9669 and A1891. In plasticised PVC films, diffusion was observed for all three silanes at room temperature. It was shown that the diffusion occurred more quickly with higher plasticiser concentrations, and hence lower glass transition temperatures. The kinetics of diffusion was found to fit a dual mode sorption model. Hydrolysis of the silanes was also followed by infrared spectroscopy, and the kinetics of hydrolysis and condensation were shown to be highly dependent upon silane type, the concentration of water, and the presence of an acid catalyst. The hydrolysis of the silanes was found to slow their diffusion through both plasticised and unplasticised PVC films. It was shown that the presence of water in the films caused the hydrolysis of the silanes in situ. Raman depth profiles were measured of the films before, during and after diffusion. The spatial resolution was shown to be adversely affected by refraction at the air / PVC interface. It was shown that it is possible to deconvolve the confocal response of the microscope from the depth profiles, resulting in greater spatial resolution. Hydrolysis of the silanes was followed in solution by Raman spectroscopy, and it was found that each of the three silanes showed different rates of hydrolysis and condensation. It was shown that it was also possible to follow the kinetics of diffusion by Raman microscopy, and the results agreed well with those shown by ATR-FTIR spectroscopy.