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Effects of Memantine on Cerebrospinal Fluid Biomarkers of Neurofibrillary PathologyGlodzik, Lidia, De Santi, Susan, Rich, Kenneth E., Brys, Miroslaw, Pirraglia, Elizabeth, Mistur, Rachel, Switalski, Remigiusz, Mosconi, Lisa, Sadowski, Martin, Zetterberg, Henrik, Blennow, Kaj, De Leon, Mony J. 01 January 2009 (has links)
Previous studies showed that memantine inhibits tau hyperphosphorylation in vitro. In this study, phosphorylated tau (P-tau) and total tau (T-tau) were measured before and after 6 month treatment with memantine in 12 subjects ranging from normal cognition with subjective memory complaints, through mild cognitive impairment to mild Alzheimer's disease. Thirteen non-treated individuals served as controls. Treatment was associated with a reduction of P-tau in subjects with normal cognition. No treatment effects were seen among impaired individuals, suggesting that longer treatment time may be necessary to achieve biomarker effect in this group.
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Transthyretin-, Aß 1-40- und Aß 1-42- und Tau-Protein-Konzentrationen im Liquor cerebrospinalis bei demenziellen Erkrankungen / Levels of Transthyretin, beta amyloid peptide 1-40/1-42 and tau protein in liquor cerebrospinalis in different kinds of dementiaGloeckner, Sara Friederike 10 November 2010 (has links)
No description available.
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