This research uses Transmissivity Index (TI) and other transmission indices to analyze the transmission performance by applying those indices to coupler-driven mechanisms with sliders. Other estimative transmission indices include Total Transmission Index (TTI) and Transmissible Mechanical Advantage (TMA). The point with best transmission performance is ¡§Effective Point,¡¨ and the combination of the effective points becomes ¡§Locus of Effective Points¡¨. In addition, this research puts the influence of mechanisms with sliders including slider-friction into consideration, and also analyzes two inverses of mechanisms with sliders. Then we can extend to study the transmission performance of six-bar mechanisms. Finally, we apply the research result into some examples, such as ping pong table mechanism, four-bar and six-bar windows operator mechanisms, rowing exercise mechanism, so that we can find the better transmission performance of those mechanisms.