Social and economic challenges in one part of the world influence budgets, security, health, and well being of populations globally as was the case with the 2014 Ebola outbreak. Deficits in healthcare, education, governance, and the economy in African nations result in financial and social contributions from the diaspora residing in the United States. Many African-born immigrants to Florida came with useful knowledge and experience from their home nations that could be a valuable resource in carrying out effective development initiatives. However, accessing that knowledge is challenging. The purpose of this research was to explore the inclusion of members of the African diaspora community in Florida nonprofit development initiatives. The transnational theory of migration underpinned the following research question: What are barriers to, and opportunities for, including members of the African diaspora in Florida-based NPOs that carry out development programs in Africa? Semistructured interviews were conducted with Florida nonprofit leaders (N= 21) who have development projects in Africa. Manual and computer assisted methods using NVivo 11 were used to develop codes and themes for data analysis. Identified barriers to including African diaspora in NPOs included lack of established networks and organizational awareness as well as limited service areas, service locations, funding, and leadership roles. All respondents expressed interest in engaging with diaspora members and other nonprofit leaders via expat networks. Successful engagement with the African diaspora community could promote positive social change by improving program delivery, communication, and programmatic outcomes for a mutual impact in both African and Florida-based communities.