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Simulated Tremor Propagation in the Upper Limb: From Muscle Activity to Joint DisplacementCorie, Thomas Henry 01 April 2018 (has links)
Although tremor is the most common movement disorder, there are few non-invasive treatment options. One of the obstacles to creating effective tremor suppression devices is our lack of understanding regarding where tremor originates (which muscles), how it propagates through the limb (to which degrees of freedom, DOF), and where it manifests most severely (which DOF). To investigate these questions, we created a simple, linear time-invariant model to simulate tremor, with tremorogenic muscle activity input (in the 15 major superficial muscles from the shoulder to the wrist) and joint displacement output (in the 7 major upper limb DOF). The model included excitation-contraction dynamics, musculoskeletal geometry (muscle moment arms) and the mechanical impedance (inertia, damping, and stiffness) of the limb. From our simulation results, we determined four principles of tremor propagation. First, the distribution of tremor depends strongly on musculoskeletal dynamics. Second, the spreading of tremor is due to inertial coupling (primarily) and musculoskeletal geometry (secondarily). Third, tremor spreads narrowly in the sense that most of the tremor caused by a muscle occurs in a small number of DOF. Lastly, assuming uniform distribution of tremorogenic activity among upper-limb muscles, tremor increases proximal-distally, and the contribution from muscles increases proximal-distally.
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Distribution of Tremorogenic Activity among the MajorSuperficial Muscles of the Upper Limb inSubjects with Essential TremorStandring, David Jordan 01 August 2019 (has links)
Optimized peripheral tremor suppression could address many limitations of surgical or medicinal treatments of Essential Tremor, however it is not well understood how the tremorogenic activity is distributed among the muscles of the upper limb, and therefore how to optimize such suppression. We recorded electromyographic (EMG) activity in the 15 major superficial muscles from the shoulder to the wrist while subjects performed postural and kinetic tasks similar to activities of daily living. We calculated the power spectral density and computed the total power in the tremor band (4"12 Hz) for each muscle, from which we determined the distribution of tremorogenic activity among the 15 muscles for various conditions. Differences in distribution between conditions were quantified as Pearson correlation coefficients. All 15 muscles exhibited some tremorogenic activity. The anterior deltoid exhibited by far the most power, the wrist extensors had more power than other distal muscles, and the triceps longus showed the least power. Distributions among muscles was highly consistent across repetitions (r = 0.91 ± 0.07) and somewhat stereotyped across subjects (r = 0.58 ± 0.31). Differences in task (postural vs. kinetic), limb configuration, and subject characteristics (sex; tremor severity, onset, and duration) had little effect on distribution (r =0.84). Interestingly, the distribution of tremorogenic activity was highly correlated (r = 0.94 ± 0.08) with the distribution of voluntary activity (power between 0.5 and 4 Hz). In particular, muscles opposing gravity had the highest amount of tremorogenic activity. This may explain in part why the distribution of tremorogenic activity was stereotyped across subjects.
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Distribution of Essential Tremor in the Degrees of Freedom of the Upper LimbPigg, Adam Charles 01 September 2017 (has links)
This study seeks to understand upper limb tremor in subjects with essential tremor (ET). A thorough understanding of tremor distribution will allow for the more effective development of tremor suppression devices, which offer an alternative to current treatments. Previous studies primarily focused on tremor in the hand only. This study seeks to characterize the distribution of tremor throughout the upper limb.We measured tremor in 25 subjects diagnosed with ET using motion capture, which provided displacement information of the limb during multiple postural and kinetic tasks. Inverse kinematics allowed us to analyze the motion capture data in the 7 major degrees of freedom (DOF) of the upper limb. The power spectral density estimate was used to determine: relative tremor magnitude throughout the DOFs, tremor variation between tasks, variation between subjects, and frequency variations between DOFs. Data analysis revealed that tremor increase is roughly proximal to distal. We also show that tremor magnitude in kinetic tasks is significantly higher than in postural tasks. Although we found some variation in tremor distribution between subjects, the roughly proximal to distal increase in tremor severity holds for several subsets of the study population. Finally, we found that tremor frequency doesnt vary significantly (< 1 Hz) between DOFs, in subjects with severe tremor. Our study shows that tremor distribution is quite stereotyped between subjects with ET. Furthermore, we have shown that tremor is greatest in the distal DOFs. This provides a compelling starting point for the development of future tremor suppression devices.
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Distribution of Essential Tremor in the Degrees of Freedom of the Upper LimbPigg, Charles Charles 01 September 2017 (has links)
This study seeks to understand upper limb tremor in subjects with essential tremor (ET). A thorough understanding of tremor distribution will allow for the more effective development of tremor suppression devices, which offer an alternative to current treatments. Previous studies primarily focused on tremor in the hand only. This study seeks to characterize the distribution of tremor throughout the upper limb. We measured tremor in 25 subjects diagnosed with ET using motion capture, which provided 0displacement information of the limb during multiple postural and kinetic tasks. Inverse kinematics allowed us to analyze the motion capture data in the 7 major degrees of freedom (DOF) of the upper limb. The power spectral density estimate was used to determine: relative tremor magnitude throughout the DOFs, tremor variation between tasks, variation between subjects, and frequency variations between DOFs. Data analysis revealed that tremor increase is roughly proximal to distal. We also show that tremor magnitude in kinetic tasks is significantly higher than in postural tasks. Although we found some variation in tremor distribution between subjects, the roughly proximal to distal increase in tremor severity holds for several subsets of the study population. Finally, we found that tremor frequency doesnt vary significantly (<<> 1 Hz) between DOFs, in subjects with severe tremor. Our study shows that tremor distribution is quite stereotyped between subjects with ET. Furthermore, we have shown that tremor is greatest in the distal DOFs. This provides a compelling starting point for the development of future tremor suppression devices.
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