Hamburg, Universiẗat, Diss., 2002.

Triazine chemistry has many applications from industrial usage, such as melamine resins, to academic interests in dendritic structures which may one day come to fruition as pharmaceutically applicable molecules. Organic synthesis, using the 1,3,5- triazine derivative 2,4,6-trichlorotriazine, cyanuric chloride, for practical applications was investigated. By utilizing the selective reactivity of cyanuric chloride, a plethora of targets from small molecules to large dendrimers may be synthesized. Triazine chemistry was adapted to an educational application for the development of an undergraduate laboratory to synthesize simazine, a widely used herbicide. The laboratory was designed to foster a sense of the applications of chemistry in the world and its effect on the environment and society. The modification of chitosan for herbicide remediation has been accomplished using triazine chemistry, as well. Treatment of chitosan iteratively with cyanuric chloride followed by piperazine produces dendritic grafts from these flakes. Dendrons of generation one through three were synthesized on chitosan backbones of low, medium, and high molecular weights. The piperazine derivatives were shown to sequester more than 99% of atrazine from an aqueous 100 ppb solution in a 24 h period. Drug delivery applications of triazine-based dendrimers were investigated. Pegylated G3 dendrimers with molecular weights of 18 and 34 kDa with 9% and 17% iodine content by weight, respectively, were synthesized as potential macromolecular contrast agents. The development of macromolecular contrast agents is of great interest to counteract the drawbacks associated with currently used, small molecule contrast media, including toxicity, extravasation into the extracellular space, and rapid clearance from the bloodstream. Dendrimers are well suited for use as macromolecular media due to the unique properties of these molecules, including monodispersity and multivalency.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1959. / Typescript. Abstracted in Dissertation abstracts, v. 20 (1959) no. 3, p. 1041-1042. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thèse univ.--Sc.--Paris 6, 1971. / Bibliogr.

No description available.

The interest in using gene therapy to target a variety of both inherited and acquired diseases has intensified over the last two decades. Because free DNA is easily degraded by serum nucleases in the bloodstream, the need for developing carrier systems that can compact and protect the DNA was quickly realized. Viral vector systems were some of the earliest carriers used, primarily because of the ease with which such systems can infect host cells. However, difficulties experienced when using viral vectors, including immunogenicity and the potential for genetic recombinations, forced researchers to design alternative delivery strategies. Non-viral vectors offer one alternative to overcome this dilemma. In addition to avoiding the biological problems experienced using viral carriers, non-viral vectors also offer the potential for large-scale production. Dendrimers are one non-viral carrier that has shown appreciable ability to deliver DNA into cells, a process called transfection. In the past, triazine dendrimers have shown biocompatibility, and the ability to synthesize these structures to contain cationic charges on the surface makes these structures potentially suitable for transfection studies. In this study, a small library of triazine dendrimers was synthesized in an attempt to understand how variations to both the periphery and core of triazine dendrimers affect the transfection efficiency of these dendriplexes. In the first subset of structures, a common core was used and various peripheral groups were appended to the dendrimer surface. The physicochemical and biological data, obtained in collaboration with Thomas Kissel at Philipps-Universitat Marburg, showed that the surface groups have a notable affect on transfection efficiency. Dendrimers with a higher amine number and neutral surface groups show high DNA binding affinity and higher transfection efficiency. In the second subset of dendrimers, variations to the core showed that transfection efficiency is improved both by increasing generation number and dendrimer flexibility. With this data in hand, triazine dendrimers with both higher generation number and higher flexibility have been synthesized. Two different triazine linker groups, trimethylene-dipiperidine and polyglycoldiamine, have been used. These structures will be evaluated to determine if increasing both flexibility and generation number together can further improve transfection efficiency.

No description available.

Bayreuth, Univ., Diss., 2010.

This thesis is divided into three main sections. The first chapter contains a brief review of nitrogen heterocyclic chemistry. The second chapter reports the results and their discussion of new heterocyclic chemistry, and the experimental details are provided in the fourth chapter.

No description available.