1 |
Validierung eines Enzymimmunoassays und Entwicklung von Standardmaterialien für die Analytik freier und gebundener TriazinrückständeTambo, Yasukazu. January 2002 (has links) (PDF)
Hamburg, Universiẗat, Diss., 2002.
|
2 |
Applications of triazine chemistry: education, remediation, and drug deliveryHatfield, Susan Elizabeth 15 May 2009 (has links)
Triazine chemistry has many applications from industrial usage, such as
melamine resins, to academic interests in dendritic structures which may one day come
to fruition as pharmaceutically applicable molecules. Organic synthesis, using the 1,3,5-
triazine derivative 2,4,6-trichlorotriazine, cyanuric chloride, for practical applications
was investigated. By utilizing the selective reactivity of cyanuric chloride, a plethora of
targets from small molecules to large dendrimers may be synthesized.
Triazine chemistry was adapted to an educational application for the
development of an undergraduate laboratory to synthesize simazine, a widely used
herbicide. The laboratory was designed to foster a sense of the applications of chemistry
in the world and its effect on the environment and society.
The modification of chitosan for herbicide remediation has been accomplished
using triazine chemistry, as well. Treatment of chitosan iteratively with cyanuric
chloride followed by piperazine produces dendritic grafts from these flakes. Dendrons
of generation one through three were synthesized on chitosan backbones of low, medium, and high molecular weights. The piperazine derivatives were shown to
sequester more than 99% of atrazine from an aqueous 100 ppb solution in a 24 h period.
Drug delivery applications of triazine-based dendrimers were investigated.
Pegylated G3 dendrimers with molecular weights of 18 and 34 kDa with 9% and 17%
iodine content by weight, respectively, were synthesized as potential macromolecular
contrast agents. The development of macromolecular contrast agents is of great interest
to counteract the drawbacks associated with currently used, small molecule contrast
media, including toxicity, extravasation into the extracellular space, and rapid clearance
from the bloodstream. Dendrimers are well suited for use as macromolecular media due
to the unique properties of these molecules, including monodispersity and multivalency.
|
3 |
Inhibition of the action of certain steroid hormones by a derivative of symmetrical triazineWilliamson, Harold Emanuel, January 1959 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1959. / Typescript. Abstracted in Dissertation abstracts, v. 20 (1959) no. 3, p. 1041-1042. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
|
4 |
Contribution à l'étude des triazines-1.2.4. trisubstituées en 3.5.6.M'Packo, Jean-Pierre. January 1900 (has links)
Thèse univ.--Sc.--Paris 6, 1971. / Bibliogr.
|
5 |
The behaviour of affinity dyes at the interface of immiscible electrolytesWiles, M. C. January 1988 (has links)
No description available.
|
6 |
The design and evaluation of triazine dendrimers for gene deliveryMintzer, Meredith Ann 2009 December 1900 (has links)
The interest in using gene therapy to target a variety of both inherited and
acquired diseases has intensified over the last two decades. Because free DNA is easily
degraded by serum nucleases in the bloodstream, the need for developing carrier systems
that can compact and protect the DNA was quickly realized. Viral vector systems were
some of the earliest carriers used, primarily because of the ease with which such systems
can infect host cells. However, difficulties experienced when using viral vectors,
including immunogenicity and the potential for genetic recombinations, forced
researchers to design alternative delivery strategies. Non-viral vectors offer one
alternative to overcome this dilemma. In addition to avoiding the biological problems
experienced using viral carriers, non-viral vectors also offer the potential for large-scale
production. Dendrimers are one non-viral carrier that has shown appreciable ability to
deliver DNA into cells, a process called transfection. In the past, triazine dendrimers
have shown biocompatibility, and the ability to synthesize these structures to contain
cationic charges on the surface makes these structures potentially suitable for
transfection studies.
In this study, a small library of triazine dendrimers was synthesized in an attempt
to understand how variations to both the periphery and core of triazine dendrimers affect
the transfection efficiency of these dendriplexes. In the first subset of structures, a
common core was used and various peripheral groups were appended to the dendrimer
surface. The physicochemical and biological data, obtained in collaboration with
Thomas Kissel at Philipps-Universitat Marburg, showed that the surface groups have a
notable affect on transfection efficiency. Dendrimers with a higher amine number and
neutral surface groups show high DNA binding affinity and higher transfection
efficiency. In the second subset of dendrimers, variations to the core showed that
transfection efficiency is improved both by increasing generation number and dendrimer
flexibility.
With this data in hand, triazine dendrimers with both higher generation number
and higher flexibility have been synthesized. Two different triazine linker groups,
trimethylene-dipiperidine and polyglycoldiamine, have been used. These structures will
be evaluated to determine if increasing both flexibility and generation number together
can further improve transfection efficiency.
|
7 |
Methods of controlling supramolecular structures in solutionAugier de Cremiers, Hugues January 2002 (has links)
No description available.
|
8 |
Designing novel host materials for blue phosphorescent organic light-emitting diodesRothmann, Michael January 2009 (has links)
Bayreuth, Univ., Diss., 2010.
|
9 |
New synthetic routes to nitrogen heterocycles : natural products and novel drug scaffoldsBu, Yubai January 2017 (has links)
This thesis is divided into three main sections. The first chapter contains a brief review of nitrogen heterocyclic chemistry. The second chapter reports the results and their discussion of new heterocyclic chemistry, and the experimental details are provided in the fourth chapter.
|
10 |
Theoretical modelling of reaction mechanisms of triazine and trinitrobenzene derivativesGooding, Stuart Robert January 2001 (has links)
No description available.
|
Page generated in 0.0548 seconds