This study attempts to list subjects in the field of Science, in which Poe had an interest. For the purpose of this study, the writer has divided the field of Science into the following heads: medicine, chemistry, biology, navigation, metrology, astronomy, physics, mathematics, and invention. Pseudo-sciences classified as: psychology, metphysics, phrenolgy, astrology, galvanism, mesmerism, logic reasoning, cryptography, and graphology.