In traffic networks, appropriately determining the traffic signal plan of each intersection is a ünecessary condition for a reasonable level of service. This paper presents the development of a new system for automatically designing optimal actuated traffic signal plans with transit signal priority. It uses an optimization algorithm combined with a mesoscopic traffic simulation model to design and evaluate optimal traffic signal plans for each intersection in the traffic network, therefore reducing the need for human intervention in the design process. The proposed method can simultaneously determine the optimal logical structure, priority strategies, timing parameters, phase composition and sequence, and detector placements. The integrated system was tested by a real-world isolated intersection in Haifa city. The results demonstrated that this approach has the potential to efficiently design signal plans without human intervention, which can minimize time, cost, and design effort. It can also help uncover problems in the design that may otherwise not be detected.