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1	Identifying potential antibiotic uptake mechanisms of Streptococcus pneumoniae Laguna Terai, Yuri 10 May 2024 (has links) (PDF) Streptococcus pneumoniae (pneumococcus) is a commensal gram-positive colonizer of the human nasopharynx capable of causing diseases including otitis media, pneumonia, bacteremia, and meningitis. Although it is often a harmless colonizer, there is a high rate of mortality and morbidity among the immunocompromised, elderly, and young children. While these infections can often be treated with antibiotics, resistance to numerous antibiotics is increasing. Antibiotic resistance is a well-studied dilemma; however, little information is known of how bacteria take up certain antibiotics. Because most antibiotics cannot diffuse freely across the bacterial cell wall, we hypothesize that metabolite transport proteins participate in the uptake of certain classes of antibiotics.
2	Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier Hsu, Charlie Yu Ming Unknown Date No description available. gene therapy non-viral gene delivery cationic polymers nucleic acid therapy targeted drug delivery transgene expression cell-based therapy intracellular trafficking transfection DNA topology nuclear import uptake pathways