No description available.

No description available.

Thesis (M.A.)--University of South Africa, 1994.

The problem was to identify the differences in attitudes of public school students at various educational levels toward selected drugs, and to determine the relationship between those attitudes and students' knowledge of drugs.

No description available.

Heart failure is a devastating disease which despite significant advances in therapy over the past two decades still results in a poor prognosis. Metabolic dysregulation is associated with heart failure; however, it remains unclear whether isoproterenol exerts deleterious effects through altered metabolic regulation. Whether metformin, a metabolic modulator, prevents isoproterenol-induced heart failure is unknown. The aim of this study was to determine whether metformin prevents functional and metabolic changes seen in the isoproterenol model of heart failure. Male Sprague-Dawley rats were administered isoproterenol and metformin for seven months. Thereafter, cardiac dimensions, metabolic gene expression and myocardial structural changes were assessed. Chronic administration of isoproterenol induced left ventricular dilatation and pump dysfunction and mitochondrial structural derangement. No changes were seen in metabolic gene expression. However, co-administration of metformin prevented isoproterenol-induced heart failure and retained mitochondrial structural arrangement. Therefore, cardiac dilatation and pump dysfunction induced by chronic administration of isoproterenol can be prevented by co-administering metformin.

A research report submitted to the Faculty of Humanities, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Arts (Drama Therapy) November 2017 / The research consists of a practical arts-based research component and a research report that surveys the practice. This document serves as the written element of the research and investigates the key theoretical standpoints, methodologies applied and creative outcomes. The research aimed to explore the dynamics of adults and play within Drama Therapy by investigating the relationship between six adult women and their personal play histories. It questioned what play meant to the individual and invited her to share her most memorable playful moments through various forms of expression in a number of individual interview-discussions. Through a practical arts-based research approach, an ethnographic narrative inquiry unfolded about women, play, childhood memory and present adulthood. The research took these shared narratives and presented them back to the six participants through various playful methods. With the use of methodologies such as inter-subjectivity, playful listening, narrative enquiry and Playback Theatre, the research offered a series of representational reflections of the shared stories. The creative outcomes were presented in a storybook representation which used imagery and poetic rhyme to document each narrative, a stop-motion film that used moving image and voice, and an presentation-installation that invited each woman to engage with her playful inner-self reflected back to her. The report is written with these playful elements which attempt to mirror the creative representational outcomes, inviting the reader to access his or her playful self. Thematically, three key factors presented themselves throughout the five-stage research process. These include the emotional experience associated with play, the notion of an inner-child or childhood and play within context. All three elements are discussed in the research report, with the use of the contextual factor symbolised by road signs to represent the intersectionality of play and its relationship to the individual. The research presents a number of key contributing factors to the discussion of adults and play in Drama Therapy. It attempts to explore alternative ways of delving into therapeutic process while respecting individual perspectives and personal narratives. It highlights the fundamental value of play within a drama therapeutic paradigm and how the notion of play and play memories contribute to the adult self. It also affirms the role of arts-based practice as a powerful tool for validation and witnessing of clients. / XL2018

Thesis submitted in fulfilment of the requirements for the degree Magister Technologiae: Chemistry in the Faculty of Applied Sciences at the CAPE PENINSULA UNIVERSITY OF TECHNOLOGY 2014 / The solid state modification of a given active pharmaceutical ingredient is a desired way to alter its physicochemical properties, such as solubility or bioavailability. The solubilitymelting point relationship of the ensuing co-crystal or salt is not fully understood. In this thesis, a series of model co-crystals and pharmaceutical co-crystals and salts of baclofen were investigated. The model co-crystals were prepared from 4,4’-bipyridine (BIPY) and 1,2-bis(4-pyridyl)ethane (ETBIPY) used as host compounds which were combined with a series of carboxylic acids as co-formers, such as p-toluic acid (PTA), rac-phenylbutyric acid (racPBA), racemic and S-phenylsuccinic acid (racPSA and S-PSA, respectively). In the second part, six new multicomponent crystals of baclofen (BAC, (RS) 4-amino-3-(4- chlorophenyl)-butanoic acid), were prepared with mono- and dicarboxylic acids: two pharmaceutical co-crystals obtained with benzoic acid (BAC•BA) and p-toluic acid (BAC•PTA) and four pharmaceutical salts with 1-hydroxy-2-naphthoic acid, (BAC+)(HNA-), oxalic acid, 2(BAC+)(OA2-), maleic acid, (BAC+)(MA-) and p-toluene sulfonic acid, (BAC+)(PTSA-)•IPA. The compounds prepared were analysed by single crystal and powder X-ray diffractometry, differential scanning calorimetry and their solubility was measured in water and ethanol. From the analysis of the model co-crystals it was concluded that their aqueous solubility is inversely related to the melting point values and this can be explained by packing features. Also, the introduction of a chiral building block, compared to its racemic counterpart, is a valuable way to limit the formation of the intermolecular interactions in the new multicomponent crystal and thus decrease the efficiency of the packing which eventually leads to lower melting points and better solubility. The analysis of the baclofen crystals suggests that a strong, robust and predictable hydrogen bonding network with a combination of molecular building blocks which show acceptable molecular flexibility is a good recipe for successful co-crystal design.

Theoretical modeling and simulation are two common approaches to the study of land use change. While theoretical models are often limited by the simplicity in their assumptions, simulations are mostly low in generalization due to their specificity in applications. The integration of these two approaches will thus help us to model more closely the reality by having a firm theoretical foundation for real-life simulation. In the present research, a theory-based cellular automata (CA) simulation is proposed to simulate the changes of land uses. The land use change generally involves urban development and urban redevelopment processes. Rent gap theory is selected as the theoretical model to describe the mechanism of urban redevelopment. On the other hand, relevant conditions related to urban development are incorporated into the simulation of new development because rent gap theory is inadequate in accounting for all mechanisms that are working together to shape the pattern of land use change. In order to perform CA simulation under random fluctuation in time, stochastic formulation of the rent gap theory is first made in the form of a build up value equation to seek for the time of appearance of rent gap. The time of urban redevelopment depends on the appearance of rent gap while the time of urban development depends on the conditions of local characteristics and government policy. To substantiate the theoretical arguments, the land use change of Hong Kong in the period of 1966--2001 is selected as a case study. For the pattern of future development of Hong Kong, the simulation is carried out up to 2016. It also serves as a basis for the evaluation of the integrative utilization of a theoretical model and a simulation method. This research demonstrates that the appropriate integration of a theoretical model and a simulation method is beneficial to the study of land use change. / Tsang Shun Wai. / "July 2007." / Advisers: Yee Leung; Tung Fung. / Source: Dissertation Abstracts International, Volume: 69-01, Section: A, page: 0334. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2007. / Includes bibliographical references (p. 215-241). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract in English and Chinese. / School code: 1307.

by Wing-yu Tang. / Bibliography: leaves 129-138 / Thesis (M.Ph.)--Chinese University of Hong Kong, 1985