The purpose of this study was to investigate whether a partial D₂-like dopamine agonist (i.e. terguride) would block the induction or expression of cocaine-induced behavioral sensitization in pre-weanling rats. The ability of terguride to induce behavioral sensitization was also examined, as partial D₂-like agonists have agonistic actions in cases of low dopaminergic tone.

Unsafe and unnecessary injections are administered in many developing and transitional countries. Injection device security is recommended in order to improve injection safety. Injection device stock depletions have been reported to contribute to unsafe injection practices. Poor distribution of health products has been reported in many parts of Uganda including Mpigi district. As a way of improving injection safety, this study explored the challenges encountered in maintaining an effective distribution system. A Cross-sectional, descriptive study of public and private-not-for-profit health care units in Mpigi district was conducted. 38 health care facilities were selected by stratified disproportionate sampling. Data on device security, the use of equipment and the distribution system were collected and analysed using descriptive statistics. / Health Studies / M.A. (Public Health)

Unsafe and unnecessary injections are administered in many developing and transitional countries. Injection device security is recommended in order to improve injection safety. Injection device stock depletions have been reported to contribute to unsafe injection practices. Poor distribution of health products has been reported in many parts of Uganda including Mpigi district. As a way of improving injection safety, this study explored the challenges encountered in maintaining an effective distribution system. A Cross-sectional, descriptive study of public and private-not-for-profit health care units in Mpigi district was conducted. 38 health care facilities were selected by stratified disproportionate sampling. Data on device security, the use of equipment and the distribution system were collected and analysed using descriptive statistics. / Health Studies / M.A. (Public Health)

Indiana University-Purdue University Indianapolis (IUPUI) / Recent work has shown that specific ALDH isoenzymes can contribute to the underlying pathology of different diseases. Many ALDH isozymes are important in oxidizing reactive aldehydes resulting from lipid peroxidation, and, thus, help maintain cellular homeostasis. Increased expression and activity of ALDH isozymes are found in many human cancers and are often associated with poor prognosis. Therefore, the development of inhibitors of the different ALDH enzymes is of interest as means to treat some of these disease states. Here I describe the results of assays designed to characterize the site of interaction and the mode of inhibition for the unique compounds that function as inhibitors of aldehyde dehydrogenase 2 and determine their respective IC50 values with intent to develop structure-activity relationships for future development.