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The effects of regulatory variation in multiple mouse tissuesCowley, Mark James, Biotechnology & Biomolecular Sciences, Faculty of Science, UNSW January 2009 (has links)
Recently, it has been shown that genetic variation that perturbs the regulation of gene expression is widespread in eukaryotic genomes. Regulatory variation (RV) is expected to be an important driver of phenotypic differences, evolutionary change, and susceptibility to complex genetic diseases. Because trans-acting regulators of gene expression control mRNA levels of multiple genes simultaneously, we hypothesise that RV that affects these components will have a shared-influence upon the expression levels of multiple genes. Since genes are regulated in trans by combinations of basal and tissue specific factors, we further hypothesise that RV in these components may have different effects in each tissue. We used microarrays to identify 755 genes that were affected by RV in at least one of the brain, kidney and liver of two inbred mouse strains, C57BL/6J and DBA/2J. Just 2% were affected in all three tissues, suggesting that the influence of RV is predominantly tissue specific. To study shared-RV, we measured the expression levels of these 755 genes in the same 3 tissues from a panel of recombinant inbred mice, and identified groups of correlated genes that are putatively under the influence of shared trans-acting RV. Using methods that we developed for studying the effects of RV in multiple tissues, we identified 212 genes that are correlated in all three tissues, which include 10 groups of at least 3 genes. We developed a novel method called coherency analysis to show that RV consistently affected the expression levels of these groups of genes in different genetic backgrounds. Strikingly, the relative up- or down-regulation of genes in each group was markedly different in the three tissues of the same mouse, suggesting that the influence of RV itself is not tissue specific as previously expected, but that RV can influence genes with differing outcomes in each tissue. These observations are compatible with RV affecting combinations of basal and tissue specific regulatory factors. This is the first cross-tissue investigation into the influence of shared-RV in multiple tissues, which has important implications in humans, where access to the phenotypically relevant tissue may be necessarily limited.
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Micropropagation, transformation and genetic diversity of Hagenia abyssinica (Bruce) J.F. Gemel /Feyissa, Tileye. January 2006 (has links) (PDF)
Diss. (sammanfattning) Alnarp : Sveriges lantbruksuniversitet, 2006. / Härtill 5 uppsatser.
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Genetic and epigenetic variation in the human genome : analysis of phenotypically normal individuals and patients affected with brain tumors /De Bustos, Cecilia, January 2006 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 5 uppsatser.
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12 variations on Paganini's 24th caprice : an analysis /Yang, Hokyung. January 1994 (has links)
Thesis (D. Mus. Arts)--University of Washington, 1994. / Vita. Includes bibliographical references (leaves [88]-92).
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Principles and parameters of syntactic saturation /Webelhuth, Gert, January 1992 (has links)
Texte remanié de: Th. Ph. D.--Amherst (Mass.)--University of Massachusetts, 1989.
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Color variation in two species of lizards (Phrynosoma modestum and Holbrookia maculata subspecies)Bundy, Roy Elton, January 1955 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1955. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 121-123).
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A graphical methodology for describing interrater variability in ordinal assessments among many raters /Nelson, Jennifer Clark. January 1999 (has links)
Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves 129-135).
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The estimation of genetic variation and divergence application to Gainj and Kalam speakers of Highland New Guinea /Long, Jeffrey Charles. January 1984 (has links)
Thesis (Ph. D.)--University of Michigan, 1984. / Includes bibliographical references.
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Long term behavior or the positive solutions of the non-autonomous difference equation : x [subscript] n+1 = A [subscript] n [superscript] x [subscript] n-1 [divided by] 1+x [subscript] n, n=0,1,2... /Bellavia, Mark R. January 2005 (has links)
Thesis (M.S.)--Rochester Institute of Technology, 2005. / Typescript. Includes bibliographical references (leaf 41).
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A survey of genetic variants in six erythrocyte proteins in Macaca mulatta and Macaca nemestrinaKulkarni, Aravind Rangrao, January 1970 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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