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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

FROM CARDIAC OPTICAL IMAGING DATA TO BODY SURFACE ECG: A THREE DIMENSIONAL VENTRICLE MODEL

Zhao, Yihua 01 January 2014 (has links)
Understanding the mechanisms behind unexplained abnormal heart rhythms is important for diagnosis and prevention of arrhythmias. Many studies have investigated the mechanisms at organ, tissue, cellular and molecular levels. There is considerable information available from tissue level experiments that investigate local action potential properties and from optical imaging to observe activity propagation properties at an organ level. By combining those electrophysiological properties together, in the present study we developed a simulation model that can help in estimation of the resulting body surface potentials from a specific electrical activity pattern within the myocardium. Some of the potential uses of our model include: 1) providing visualization of an entire electrophysiological event, i.e. surface potentials and associated source which would be optical imaging data, 2) estimation of QT intervals resulting from local action potential property changes, 3) aiding in improving defibrillation therapy by determining optimal timing and location of shocks.

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