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1	On α-synuclein in the Human Enteric Nervous System Gray, Madison T. 25 February 2014 (has links) Parkinson’s disease is a neurodegenerative disease resulting primarily from loss of dopaminergic innervation in the striatum subsequent to cell loss in the substantia nigra pars compacta. The abnormal accumulation of the normal pre-synaptic protein α-synuclein (αsyn) forms intraneuronal inclusions known as Lewy neurites and Lewy bodies. The origins of central Lewy pathology have been suggested to lie in the enteric nervous system, ascending through the vagus nerve to the dorsal motor nucleus of the vagus. To ascertain gastrointestinal regions most likely to be the source of central Lewy pathology, αsyn expression was evaluated in the neural elements of gastrointestinal regions receiving the densest vagal innervation. The vermiform appendix was found to have the densest αsyn-immunoreactive innervation in all layers of the gut wall. In addition, macrophages in the appendiceal mucosa were laden with αsyn within lysosomes, consistent with attempts to prevent the spread of disease or to correct synaptic dysfunction. α-synuclein alpha-synuclein Parkinson's disease Enteric nervous system vermiform appendix Lewy bodies gastrointestinal
2	On α-synuclein in the Human Enteric Nervous System Gray, Madison T. January 2014 (has links) Parkinson’s disease is a neurodegenerative disease resulting primarily from loss of dopaminergic innervation in the striatum subsequent to cell loss in the substantia nigra pars compacta. The abnormal accumulation of the normal pre-synaptic protein α-synuclein (αsyn) forms intraneuronal inclusions known as Lewy neurites and Lewy bodies. The origins of central Lewy pathology have been suggested to lie in the enteric nervous system, ascending through the vagus nerve to the dorsal motor nucleus of the vagus. To ascertain gastrointestinal regions most likely to be the source of central Lewy pathology, αsyn expression was evaluated in the neural elements of gastrointestinal regions receiving the densest vagal innervation. The vermiform appendix was found to have the densest αsyn-immunoreactive innervation in all layers of the gut wall. In addition, macrophages in the appendiceal mucosa were laden with αsyn within lysosomes, consistent with attempts to prevent the spread of disease or to correct synaptic dysfunction. α-synuclein alpha-synuclein Parkinson's disease Enteric nervous system vermiform appendix Lewy bodies gastrointestinal
3	The Nematalycidae (Acariformes): An exploration of large-scale morphological variation and evolution using low-temperature scanning electron microscopy Bolton, Samuel John 14 September 2016 (has links) No description available. Animal Sciences Entomology Morphology Acari Endeostigmata SEM morphology systematics phylogenetics Osperalycus Cunliffea Gordialycus Eriophyoidea mouthparts gnathosoma microbivory locomotion vermiform

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