Understanding how neurons in the primary visual cortex (V1) of primates respond to visual patterns has been a major focus of research in neuroscience for many decades. Numerous different experimental techniques have been used to provide data about how the spatiotemporal patterns of light projected from the visual environment onto the retina relate to the spatiotemporal patterns of neural activity evoked in the visual cortex, across disparate spatial and temporal scales. However, despite the variety of data sources available (or perhaps because of it), there is still no unified explanation for how the circuitry in the eye, the subcortical visual pathways, and the visual cortex responds to these patterns. This thesis outlines a research project to build computational models of V1 that incorporate observations and constraints from an unprecedented range of experimental data sources, reconciling each data source with the others into a consistent proposal for the underlying circuitry and computational mechanisms. The final mechanistic model is the first one shown to be compatible with measurements of: (1) temporal firing-rate patterns in single neurons over tens of milliseconds obtained using single-unit electrophysiology, (2) spatiotemporal patterns in membrane voltages in cortical tissues spanning several square millimeters over similar time scales, obtained using voltage-sensitive-dye imaging, and (3) spatial patterns in neural activity over several square millimeters of cortex, measured over the course of weeks of early development using optical imaging of intrinsic signals. Reconciling this data was not trivial, in part because single-unit studies suggested short, transient neural responses, while population measurements suggested gradual, sustained responses. The fundamental principles of the resulting models are (a) that the spatial and temporal patterns of neural responses are determined not only by the particular properties of a visual stimulus and the internal response properties of individual neurons, but by the collective dynamics of an entire network of interconnected neurons, (b) that these dynamics account both for the fast time course of neural responses to individual stimuli, and the gradual emergence of structure in this network via activity-dependent Hebbian modifications of synaptic connections over days, and (c) the differences between single-unit and population measurements are primarily due to extensive and wide-ranging forms of diversity in neural responses, which become crucial when trying to estimate population responses out of a series of individual measurements. The final model is the first to include all the types of diversity necessary to show how realistic single-unit responses can add up to the very different population-level evoked responses measured using voltage-sensitive-dye imaging over large cortical areas. Additional contributions from this thesis include (1) a comprehensive solution for doing exploratory yet reproducible computational research, implemented as a set of open-source tools, (2) a general-purpose metric for evaluating the biological realism of model orientation maps, and (3) a demonstration that the previous developmental model that formed the basis of the models in this thesis is the only developmental model so far that produces realistic orientation maps. These analytical results, computational models, and research tools together provide a systematic approach for understanding neural responses to visual stimuli across time scales from milliseconds to weeks and spatial scales from microns to centimeters.

Measurement of visual quality is crucial for various image and video processing applications. <br /><br /> The goal of objective image quality assessment is to introduce a computational quality metric that can predict image or video quality. Many methods have been proposed in the past decades. Traditionally, measurements convert the spatial data into some other feature domains, such as the Fourier domain, and detect the similarity, such as mean square distance or Minkowsky distance, between the test data and the reference or perfect data, however only limited success has been achieved. None of the complicated metrics show any great advantage over other existing metrics. <br /><br /> The common idea shared among many proposed objective quality metrics is that human visual error sensitivities vary in different spatial and temporal frequency and directional channels. In this thesis, image quality assessment is approached by proposing a novel framework to compute the lost information in each channel not the similarities as used in previous methods. Based on natural scene statistics and several image models, an information theoretic framework is designed to compute the perceptual information contained in images and evaluate image quality in the form of entropy. <br /><br /> The thesis is organized as follows. Chapter I give a general introduction about previous work in this research area and a brief description of the human visual system. In Chapter II statistical models for natural scenes are reviewed. Chapter III proposes the core ideas about the computation of the perceptual information contained in the images. In Chapter IV, information theoretic criteria for image quality assessment are defined. Chapter V presents the simulation results in detail. In the last chapter, future direction and improvements of this research are discussed.

Measurement of visual quality is crucial for various image and video processing applications. <br /><br /> The goal of objective image quality assessment is to introduce a computational quality metric that can predict image or video quality. Many methods have been proposed in the past decades. Traditionally, measurements convert the spatial data into some other feature domains, such as the Fourier domain, and detect the similarity, such as mean square distance or Minkowsky distance, between the test data and the reference or perfect data, however only limited success has been achieved. None of the complicated metrics show any great advantage over other existing metrics. <br /><br /> The common idea shared among many proposed objective quality metrics is that human visual error sensitivities vary in different spatial and temporal frequency and directional channels. In this thesis, image quality assessment is approached by proposing a novel framework to compute the lost information in each channel not the similarities as used in previous methods. Based on natural scene statistics and several image models, an information theoretic framework is designed to compute the perceptual information contained in images and evaluate image quality in the form of entropy. <br /><br /> The thesis is organized as follows. Chapter I give a general introduction about previous work in this research area and a brief description of the human visual system. In Chapter II statistical models for natural scenes are reviewed. Chapter III proposes the core ideas about the computation of the perceptual information contained in the images. In Chapter IV, information theoretic criteria for image quality assessment are defined. Chapter V presents the simulation results in detail. In the last chapter, future direction and improvements of this research are discussed.

This work explores a novel vision model based coding approach to encode medical images at a perceptually lossless quality, within the framework of the JPEG 2000 coding engine. Perceptually lossless encoding offers the best of both worlds, delivering images free of visual distortions and at the same time providing significantly greater compression ratio gains over its information lossless counterparts. This is achieved through a visual pruning function, embedded with an advanced model of the human visual system to accurately identify and to efficiently remove visually irrelevant/insignificant information. In addition, it maintains bit-stream compliance with the JPEG 2000 coding framework and subsequently is compliant with the Digital Communications in Medicine standard (DICOM). Equally, the pruning function is applicable to other Discrete Wavelet Transform based image coders, e.g., The Set Partitioning in Hierarchical Trees. Further significant coding gains are ex ploited through an artificial edge segmentation algorithm and a novel arithmetic pruning algorithm. The coding effectiveness and qualitative consistency of the algorithm is evaluated through a double-blind subjective assessment with 31 medical experts, performed using a novel 2-staged forced choice assessment that was devised for medical experts, offering the benefits of greater robustness and accuracy in measuring subjective responses. The assessment showed that no differences of statistical significance were perceivable between the original images and the images encoded by the proposed coder.

In jeder Produktentwicklung ist besonders die Abstimmung deren Ziele und Inhalte zu Beginn wichtig. Klare Kommunikation und übereintreffendes Verständnis der Aufgabenstellung legen den Grundstein für eine erfolgreiche Entwicklung. Bisher werden Entwicklungsziele im Maschinenbau hauptsächlich in detaillierten Anforderungslisten (Peschges, 2015), Pflichtenheften und Lastenheften (Bender et al., 2018, Jacoby, 2019) festgehalten, die aufgrund ihres Detaillierungsgrades nicht auf einen Blick erfassbar oder präsentierbar sind. Auch in anderen Branchen gibt es Methoden zur Zieldefinition, die jedoch meist nur Teilaspekte einer Entwicklung abbilden können. Im Industriedesign beispielsweise wird unter anderem mit sogenannten schriftlichen Design Briefs (Rao, 2017) gearbeitet, die die Entwicklungsziele feststecken. Mithilfe des Visionsmodells werden verschiedene Herangehensweisen in Kombination mit Erfahrungswissen aus der Industrie zu einer ganzheitlichen und verständlichen Methode verbunden. [... aus der Einleitung]