The purpose of this study was to examine the effects of Vitamin E deficiency and/or ionizing radiation on uterine ceroidogenesis, incisor depigmentation, serum Vitamin E, haemoglobin concentration, haematocrit, 2,3-DPG and adipose tissue fatty acid composition in rats. An attempt was also made to define the nature of ceroid and to examine its relationship to lipofuscin. Rats fed a Vitamin E deficient diet deposited increasing amounts of ceroid in the uterine musculature between 90 to 261 days after the imposition of the experimental diets. This pigment was found to be essentially similar to lipofuscin. Ionizing radiation did not have any apparent effect on the rate and degree of ceroidogenesis in Vitamin E deficient rats, althought it did cause a significant decrease in the serum Vitamin E levels of both Vitamin E deficient and supplemented animals. The serum Vitamin E of the deficient animals were significantly lower than those of the supplemented animals, irrespective of their radiation status. Vitamin E deficiency also caused a depigmentation of the maxillary incisors of the animals and had no effect on the haemoglobin concentration, haematocrit and 2,3-DPG levels of these rats. Finally, Vitamin E deficiency and ionizing radiation resulted in a decrease in the polyunsaturated fatty acid content of adipose tissues. / Education, Faculty of / Curriculum and Pedagogy (EDCP), Department of / Graduate

The effect of the dietary status of vitamin A on carbohydrate metabolism, postmortem isometric tension development and shear resistance of Pectoral is major muscle was studied. Depletion studies, conducted over a five week period, indicated a definite influence of vitamin A deficiency on muscle carbohydrate metabolism. Mild hypovitaminosis A induced an increase in glycogen deposition whereas a severe deficiency led to a reduction of these elevated stores. Vitamin A deficiency did not affect the abi I ity of P. major strips to develop isometric tension postmortem. P. major strips sampled from deficient cockerels generally required longer to reach maximum tension and, in the later stages, developed significantly greater maximum tension than those of controls. The extended times to maximum tension reflected an increased muscle glycogen content. A significant increase in shear value similarly corresponded to the increased myofibrillar contraction noted in the later deficiency stages. Cockerels which had previously received a completely vitamin A deficient ration for five weeks were utilized for the two week repletion study. Though there was a distinct delay in response to the feeding of a vitamin A adequate ration, the muscle glycogen content, isometric tension parameters and shear values of repleted birds were similar to those of controls within the two week period. / Land and Food Systems, Faculty of / Graduate

Thesis (D.P.H.)--University of Michigan, 1994.

Thesis (D.P.H.)--University of Michigan, 1994.

Typescript, etc. / Digitized by Kansas State University Libraries

Call number: LD2668 .T4 1944 K6 / Master of Science

Call number: LD2668 .T4 1951 W58 / Master of Science

No description available.

No description available.

Thesis (M.Pub.Health) - University of Queensland, 2006. / Includes bibliography.