This thesis critically explores the issue of access to biological resources and Indigenous knowledge Historically, biological resources collected and documented, and knowledge associated with their use, have been considered the 'common heritage of mankind' The Convention on Biological Diversity (CBD) changed this understanding to tights of states over biological resources, but also gave rise to issues of equity and justice, especially with regard to Indigenous Nations encapsulated within First World states-so-called 'Fourth World Nations', A central concern of Fourth World Peoples is their marginalisation within access negotiations, despite their claims of connate (birth) rights to r esou.r ces and knowledge they identify as their own. Increasing global Indigenous activism over their concerns, has in turn raised an increasingly important policy gap that is becoming recognised in fora and processes with regard to access to biological resources. My thesis addresses this policy gap. I explore some of the complex historical, political and cultural dimensions that led to the emergence and resilience of this policy problem The failure to address the concerns of Indigenous peoples, and Fourth World Nations in particular, is more important and problematic now because of contemporary biotechnological developments and the emergence of bioprospecting. Bioprospecthg refers to the practice of appropriating biological resources, and Indigenous knowledge of those resources, and incorporating them into biopharmaceutical processes. Literature on bioprospecting as a problematic issue for Third World States has been emerging steadily over the last decade under the impact of the commercialisation of biodiversity, which has become big business for biopha.rmaceutical companies. The unique interests and experiences of Fourth World Nations are not recognised within this literature as significantly different to that of the Third World, and of their encapsulating states.. This study has addressed this significant gap by utilising and developing an analytical approach that uses Fourth World theory, synthesised with elements of Foucault's analytics of power. When combined, these two theoretical approaches provide a new and rich under standing of how dominant 'ways of knowing' and 'ways of owning' have been privileged, while other knowledge and ownership systems have been, and continue to be, marginalised, Eoucault's understanding of discursive power as having the capability to be either, or both, dominant and resistant is important to my analysis, as it accommodates the Fourth World as a discursive site of resistance to dominant power. I posit that richer insights are gained through the development and application of this theoretical framework to the issue of fair and equitable access to biological resources, than other approaches offer. I demonstrate the framework's utility by applying it to a case study on bioprospecting in Australia. Important findings have emerged while tracking the activities of Fourth World peoples on the international stage, and their attempts to challenge dominant power/knowledge structures within political institutions For example, participation at the international level has enabled Fomth World peoples to apply pressure on their encapsulating states to accommodate their interests. This has been furthered through forming alliances with, for example, environmentalists, and through the adoption of the language of effective participation within international fora.. Overall, however, the study found that the participation of Eourth World peoples within international, central state and local state policy processes is not always empowering in challenging dominant interests Instead, the more accurate impression is that at this stage of the discursive policy terrain, it may only create an illusion of participation that actually serves to entrench their disempowerment. This places pressule on policy processes to address and resolve this access issue equitably if social turbulence is to subside, justice be served, and certainty provided for all.