Weed control is challenging for Mississippi peanut producers. Research was established during 2017 and 2018 at the Delta Research and Extension Center in Stoneville, Mississippi, to evaluate herbicide programs for weed control and reducing weed seed production in Mississippi peanut production. Treatments were combinations of acetochlor, clethodim, flumioxazin, lactofen, paraquat, and S-metolachlor with their respective adjuvants if needed. Treatments were applied: PRE, early-POST (EPOST), and/or mid-post (MPOST). All treatments included a PRE application followed by (fb) application of EPOST and/or MPOST application. Flumioxazin PRE fb lactofen plus clethodim MPOST provided greatest weed control and peanut yield. This treatment provided 88 to 100% control of barnyardgrass, hemp sesbania, Palmer amaranth, pitted morningglory, and prickly sida. Additionally, this treatment reduced total weed seed production 88% compared to the nontreated control. Flumioxazin PRE fb lactofen plus clethodim EPOST fb acetochlor MPOST provided similar weed control and peanut yield as flumioxazin PRE fb lactofen plus clethodim MPOST. This treatment provided 88 to 100% control of all weed species present and reduced total weed seed production 93%. Sequential applications of PRE, EPOST, and/or MPOST herbicide treatments provided the best season-long control of weeds and weed seed suppression in Mississippi peanut.