Short-lived rodents are sensitive to changes in environmental conditions and exhibit annual fluctuations under seasonal environments in northern temperate regions. I analyzed 34 years of monthly live-trapping data on whiteooted mice (Peromyscus leucopus) collected in Carter Woods, Ohio. I used a theoretic-information approach to select the best approximating models and analysis of deviance to infer effects of climate and density on survival of mice. I tested for a cost of reproduction to females and found no difference in survival between reproductive states. Directions and magnitudes of effects of climate and density varied over time. Increased variability in temperature reduced effects of density on survival. I detected an Allee effect and density dependent effects on survival. Long-term trapping data are needed to study temporal effects of climate and density on the demography of rodents. Recruitment had a greater impact on population growth rate than survival