The interaction between wind turbines in simple wind farm layouts is investigated with the purpose of observing the influence of wake loss phenomenon on the energy production of downwind turbines. Following an intensive exploration stage about wind farm aerodynamics and wake modeling subjects, several tests cases are designed to represent various wind farm configurations, consisting of different number of wind turbines. These cases are simulated by using DNV GL WindFarmer software which provides the opportunity of performing simulations with two different wake modeling techniques, namely Modified PARK and Eddy Viscosity. Various terrain and ambient turbulence intensity conditions are considered during the test cases. Also three different turbine types having different hub heights, rotor diameters and power-thrust coefficients are used in order to observe the effect of turbine characteristics on wake formation. Besides WindFarmer, WAsP and MATLAB tools are used in some simulation stages in order to generate input data such as wind and terrain conditions or farm layout configurations; and to process the data obtained in the end of these test cases. Simulations which are executed in the presence of a predominant wind direction from a narrow direction bin indicate that, even though there exists no significant interaction between the turbines placed in abreast configurations, successive turbine rows affect each other strongly due to the existence of the wake region of upwind turbines. It is observed that downwind spacing between turbine rows required to recover wake deficit up to a certain level changes depending on terrain and ambient turbulence intensity conditions together with turbine characteristics. For instance increasing surface roughness length (or ambient turbulence intensity) of a given site by keeping all the other parameters constant can provide up to 20% (or 30%) decrease in the required downstream distance to reduce wake loss to 5% level in a simple tandem layout consisting of two wind turbines. Further test cases are executed with various numbers of wind turbines in different configurations to observe the effect of partial, full and multiple wake regions on total farm efficiency. The results obtained from these cases are used in order to have a comparison between several farm layouts and evaluate their advantages and drawbacks.