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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Beobachten und Ertasten zellulärer Maschinen

Heisenberg, Carl-Philipp, Müller, Daniel J. 04 October 2007 (has links)
Wie erledigen zelluläre Maschinen ihre Aufgaben? Wie funktionieren sie? Zur Beantwortung dieser Fragen werden in unserer wissenschaftlichen Arbeitsgruppe bionanotechnologische Methoden entwickelt, die es ermöglichen, diese nur wenige Nanometer großen Maschinen bei der Ausübung ihrer Arbeiten zu beobachten. Gleichzeitig detektieren diese Methoden molekulare Wechselwirkungsmechanismen, die die einzelnen Maschinen der Zelle steuern. Erste Beispiele zeigen den Einfluss pharmazeutischer Wirkstoffe zur Regulierung der Proteinfunktion im molekularen Detail. Hierdurch werden völlig neue Möglichkeiten geschaffen, um molekulare Schalter zellulärer Maschinen zu finden und zu betätigen. / How do cellular machines function to fulfil their specific tasks so efficiently? How are they regulated? We apply and develop bio-nanotechnological approaches to directly observe these nanoscale cellular machines while they are at work. At the same time, we can gain insights into the working schedule of a cell, and can detect molecular mechanisms which drive and direct single cellular machines. With this unique possibility to reveal the switching mechanisms of the cellular machines, we could apply these switches to purposefully direct and regulate cellular processes. First examples follow the actions of pharmacological compounds on the function of a cellular machine at molecular resolution, and provide hitherto unexpected perspectives to develop and optimise such compounds to precisely target the function of cellular processes.

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