International Telemetering Conference Proceedings / October 28-31, 1996 / Town and Country Hotel and Convention Center, San Diego, California / The science payload for NASA's Extreme Ultraviolet Explorer (EUVE) satellite is controlled from the EUVE Science Operations Center (ESOC) at the Center for EUV Astrophysics (CEA), University of California, Berkeley (UCB). The ESOC is in the process of a transition from a single staffed shift to an autonomous, zero-shift, "lights out" science payload operations scenario (a.k.a., 1:0). The purpose of the 1:0 transition is to automate all of the remaining routine, daily, controller telemetry monitoring and associated "shift" work. Building on the ESOC's recent success moving from three-shift to one-shift operations (completed in Feb 1995), the 1:0 transition will further reduce payload operations costs and will be a "proof of concept" for future missions; it is also in line with NASA's goals of "cheaper, faster, better" operations and with its desire to out-source missions like EUVE to academe and industry. This paper describes the 1:0 transition for the EUVE science payload: the purpose, goals, and benefits; the relevant science payload instrument health and safety considerations; the requirements for, and implementation of, the multi-phased approach; a cost/benefit analysis; and the various lessons learned along the way.