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The study of human palaeopathology has developed considerably in the last three decades resulting in a structured and standardised framework of practice, based upon skeletal lesion patterning and differential diagnosis. By comparison, disarticulated zooarchaeological assemblages have precluded the observation of lesion distributions, resulting in a dearth of information regarding differential diagnosis and a lack of standard palaeopathological recording methods. Therefore, zoopalaeopathology has been restricted to the analysis of localised pathologies and ‘interesting specimens’. Under present circumstances, researchers can draw little confidence that the routine recording of palaeopathological lesions, their description or differential diagnosis will ever form a standard part of zooarchaeological analysis. This has impeded the understanding of animal disease in past society and, in particular, has restricted the study of systemic disease. This research tackles this by combining the disciplines of human palaeopathology and zoopalaeopathology and focusing on zoonotic disease. The primary aim of this research was to investigate the skeletal manifestation of bTB in cattle, sheep/goat and pig to establish differential diagnostic criteria for its identification in zooarchaeological assemblages. Methods commonplace in human palaeopathology were adapted and applied to zoopalaeopathology, in addition to radiography and aDNA analysis. The results emphasise the difficulties but also the potential associated with the identification of systemic diseases in zooarchaeological assemblages. An approach to the classification of potentially infectious lesions is presented that enables the calculation of crude prevalence in disarticulated assemblages. In addition, the potential for a DNA analysis to shed further light on animal disease in the past is emphasised. / Arts and Humanities Research Council (AHRC) / Many of the images have been removed from the online version due to copyright restrictions. The embargo period for the thesis ended: 16th January 2018.