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Effect of Cannabinoids on Osteogenic Differentiation of Cultured Vascular Smooth Muscle Cells

Vascular calcification is strongly correlated with the clinical manifestations of atherosclerosis, heart attacks and strokes. The calcification process resembles bone formation and involves the osteogenic trans-differentiation of smooth muscles cells within the arterial wall. Cannabinoid receptors are known to modulate bone formation and are present in atherosclerotic vessels, suggesting they may also play a role in modulating calcification. Therefore, we evaluated the effects of cannabinoids on the expression of osteogenic proteins by vascular smooth muscle cells undergoing calcification.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:honors-1399
Date01 May 2017
CreatorsEccles, Bree A
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceUndergraduate Honors Theses
RightsCopyright by the authors., http://creativecommons.org/licenses/by-nc-nd/3.0/

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