by Cathy Yui Hung. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 129-152). / Abstract --- p.i / List of A bbreviations --- p.iv / Table of Contents --- p.vii / Chapter CHAPTER 1 --- INTRODUCTION / Chapter 1. --- Definitions & Morbid implication of PIH / Chapter 1.1. --- Definition of PIH --- p.1 / Chapter 1.2. --- Classification --- p.2 / Chapter 1.3. --- Background --- p.3 / Chapter 2. --- Aetiology PIH --- p.4 / Chapter 2.1. --- Anatomy of placenta --- p.4 / Chapter 2.2. --- Physiology of placenta --- p.4 / Chapter 2.3. --- The placenta as the cause of PIH --- p.6 / Chapter 2.4. --- Pathology of the placental bed --- p.7 / Chapter 3. --- Epidemiology of PIH --- p.9 / Chapter 3.1. --- Maternal risk factors --- p.9 / Chapter 3.2. --- Fetal risk factors --- p.10 / Chapter 3.3. --- Genetics of PIH --- p.10 / Chapter 3.4. --- Maternal outcome --- p.12 / Chapter 3.5. --- Fetal outcome --- p.13 / Chapter 4. --- Pathophysiologic changes in PIH --- p.14 / Chapter 4.1. --- Important Pathophysiologic changes in PIH --- p.14 / Chapter 4.1.1. --- Hyperdynamic circulation --- p.14 / Chapter 4.1.2. --- Changes in Intravascular volume --- p.15 / Chapter 4.1.3. --- Loss of resistance to Angiotensin II and catecholamines --- p.16 / Chapter 4.1.4. --- Coagulation abnormalities --- p.16 / Chapter 4.1.5. --- Platelets --- p.17 / Chapter 4.2. --- Multisystem disorder in PIH --- p.18 / Chapter 4.2.1. --- The kidney --- p.18 / Chapter 4.2.2. --- The liver --- p.19 / Chapter 4.2.3. --- The brain and nervous system --- p.19 / Chapter 4.2.4. --- Cardiovascular and renin-angiotensin systems --- p.20 / Chapter 4.2.5. --- Placenta --- p.21 / Chapter 5. --- Prediction of PIH --- p.22 / Chapter 5.1. --- Standard methods of antental care --- p.22 / Chapter 5.1.1. --- Blood pressure increase in antenatal period --- p.22 / Chapter 5.1.2. --- Second Trimester Mean Arterial Pressure --- p.23 / Chapter 5.1.3. --- Proteinuria --- p.25 / Chapter 5.1.4. --- Excessive weight gain and edema --- p.26 / Chapter 5.1.5. --- Platelet count --- p.27 / Chapter 5.2. --- Vasoconstriction tests --- p.27 / Chapter 5.2.1. --- The Isometric Handgrip Exercise Test --- p.27 / Chapter 5.2.2. --- Roll-Over Test --- p.28 / Chapter 5.2.3. --- Infusion of Angiotensin II --- p.31 / Chapter 5.3. --- Biochemical tests --- p.33 / Chapter 5.3.1. --- Urinary Calcium excretion --- p.33 / Chapter 5.3.2. --- Prostacyclin & throboxane A2 --- p.33 / Chapter 5.3.3. --- Platelet Angiotensin II receptors --- p.34 / Chapter 5.4. --- Ultrasougographic evaluation --- p.36 / Chapter 5.4.1. --- Doppler waveforms of uteroplacental circulation --- p.36 / Chapter 6. --- Prevention & treatment of PIH --- p.38 / Chapter 6.1. --- Antihypertensive drugs --- p.40 / Chapter 6.2. --- Antithrombotic agents --- p.40 / Chapter 6.2.1. --- Low-dose aspirin --- p.40 / Chapter 6.3. --- Calcium supplementation --- p.44 / Chapter CHAPTER 2 --- General Methodology / Chapter 1.1 --- Introduction --- p.48 / Chapter 1.2. --- Materials --- p.48 / Chapter 2. --- Studies --- p.51 / Chapter 2.1. --- Validation of Cor-7000 Sphygmomanometer --- p.51 / Chapter 2.1.1. --- Patients --- p.51 / Chapter 2.1.2. --- Methods --- p.51 / Chapter 2.1.3. --- Statistics --- p.52 / Chapter 2.1.4. --- Results --- p.53 / Chapter 2.2. --- Platelet ANG II receptor status and systemic vascular resistance --- p.58 / Chapter 2.2.1. --- Control subjects --- p.58 / Chapter 2.2.2. --- Patient subjects --- p.58 / Chapter 2.2.3. --- Platelet preparation and platelet angiotensin II binding site assay --- p.60 / Chapter 2.2.3.1. --- Statistical analysis --- p.62 / Chapter 2.2.3.2. --- Results --- p.63 / Chapter 2.2.4. --- Using impedance techniques to measurement of systemic vascular resistance --- p.74 / Chapter 2.2.4.1. --- Measurement of Cardiac Output by impedance cardiography --- p.74 / Chapter 2.2.4.2. --- Validity of transthoracic electrical bioimpedance technique --- p.81 / Chapter 2.2.4.3. --- Measurement of mean arterial pressure --- p.87 / Chapter 2.2.4.3.1. --- Experimental technique --- p.87 / Chapter 2.2.4.3.2. --- Statistical analysis --- p.92 / Chapter 2.2.4.4. --- Results --- p.92 / Chapter 2.2.4.5. --- Data analysis --- p.93 / Chapter 2.2.4.6. --- Relationship between platelet ANG II binding and haemodynamic indices --- p.110 / Chapter 2.2.4.7. --- pregnancy outcome --- p.115 / Chapter CHAPTER 3. --- RESULTS / Chapter 1. --- Study 1 Validation of Cor 7000 sphygmomanometer --- p.116 / Chapter 2. --- Study 2 Platelet ANG II receptor status and systemic vascular resistance --- p.118 / Chapter 2.1. --- Platelet Angiotensin II binding Assay --- p.118 / Chapter 2.2. --- Limitation of the TEB technique --- p.121 / Chapter 2.3. --- Changes in blood pressure and other cardiovascular indices --- p.122 / Chapter 2.4. --- Relationship between Platelet ANG II binding and Haemodynamic indices --- p.124 / Chapter CHAPTER 4 --- CONCLUSION / Chapter 4.1. --- Conclusion --- p.126 / References --- p.129 / Acknowledgments
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_322023 |
| Date | January 1997 |
| Contributors | Hung, Cathy Yui., Chinese University of Hong Kong Graduate School. Division of Surgical Sciences. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, xiii, 152, [18] leaves : ill. ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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