The doctoral dissertation: Searching for pathomechanisms of late-life minor depression – a combined MRI, biomarker and meta-analytic study was one of the first studies investigating the underlying pathophysiology of minor depression.
The dissertation comprises a systematic review of the prevalence rates of minor depression, two meta-analyses of peripheral BDNF changes in major depressive disorder, as well as two original studies investigating serum BDNF, S100B and NSE levels and gray matter changes in minor depression.
The limitations of studies and proposed improvements to the study design are discussed extensively.:1. INTRODUCTION
1.1 Motivation
1.1.1 Minor depression in the spectrum of psychiatric disorders
1.1.2 Minor depression is prevalent but unrecognized.
1.2 Theoretical background
1.2.1 Overview of depression hypotheses
1.2.2 Neurotrophic hypothesis of depressive disorders
1.2.3 Glial hypothesis of depressive disorders
1.2.4 Structural neuroimaging changes in major depression
1.3. Rationale and hypotheses of the empirical studies
1.3.1 Research questions
1.3.2 Research hypotheses
2. EMPIRICAL STUDIES
2.1 The prevalence of minor depression in the late life
2.2 The meta-analysis of BDNF changes in mood disorders
2.3 The meta-analysis of BDNF changes following ECT in depression
2.4 Serum biomarkers in minor depression
2.5 Structural brain imaging in minor depression
3. GENERAL DISCUSSION
3.1 Summary of results
3.2 Implications for research
3.3 Implications for clinical studies
SUMMARY
REFERENCES
APPENDIX A: DECLARATION OF CONTRIBUTION
APPENDIX B: STATEMENT OF AUTHORSHIP
APPENDIX C: CURRICULUM VITAEAPPENDIX D: ACADEMIC CONTRIBUTIONS
APPENDIX E: ACKNOWLEDGMENT
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:34038 |
| Date | 21 May 2019 |
| Creators | Polyakova, Maryna |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/acceptedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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