本研究では、聴覚神経系で入力の統合を担う下丘におけるシナプス伝達特性の生後発達段階における変化について、シナプス電流をパッチクランプ法で計測した。NMDA-EPSCにおいて、聴覚入力開始後に減衰時間が短縮していた。上行性経路からのシナプス伝達では、発達段階に応じて短期シナプス可塑性が変化した。一方で、交連性経路からのシナプス伝達では、発達段階に伴う短期シナプス可塑性の傾向には有意な変化はなかった。 / The inferior colliculus (IC) is the primal center of convergence and integration in the auditory pathway. I have measured excitatory synaptic currents (EPSCs) of the neurons in the central nucleus of the IC in response to stimulation of the lateral lemniscus and the commissure of the IC. Before hearing onset, the lemniscus inputs exhibited short-term depression, whereas commissural inputs showed facilitation. After hearing onset, the NMDA-EPSCs exhibited faster decay for both pathways. Furthermore, the EPSCs showed less short-term plasticity in both pathways. These developmental changes may ensure faster and more reliable signal transmission to the IC after onset of hearing. / 博士(理学) / Doctor of Philosophy in Science / 同志社大学 / Doshisha University
| Identifer | oai:union.ndltd.org:doshisha.ac.jp/oai:doshisha.repo.nii.ac.jp:00001623 |
| Date | 22 March 2020 |
| Creators | 北川 真子, Mako Kitagawa |
| Source Sets | Doshisha University |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | application/pdf |
| Source | https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13127446/?lang=0 |
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