The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites.

Description

No / Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an antimalarial drug in Central and Western Africa, has been found to bind to DNA in a formerly unknown intercalation mode. Evidence from competition dialysis assays demonstrates that cryptolepine is able to bind CG-rich sequences containing nonalternating CC sites. Here we show that cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)2 in a base-stacking intercalation mode.

Links & Downloads

1. Lisgarten, J. N., Coll, M., Portugal, J., Wright, C. W. and Aymami, J. (2001). The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites. Nature Structural Biology, Vol. 9, pp. 57 - 60.
2. http://hdl.handle.net/10454/4045
3. https://doi.org/10.1038/nsb729

Tags

Cryptolepine

Indoloquinoline alkaloid

Antimalarial drugs

DNA intercalation

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/4045
Date	January 2001
Creators	Lisgarten, J.N., Coll, M., Portugal, J., Wright, Colin W., Aymami, J.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository