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Regulation of PGC-1 alpha in White Adipose Tissue by Exercise

This project investigated the effects of exercise and epinephrine on the mRNA expression of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1 alpha), a master regulator of mitochondrial biogenesis, in rat adipose tissue. Rats that swam 2 hours daily for 4 weeks had increased mitochondrial marker proteins and PGC-1 alpha mRNA expression in epididymal and retroperitoneal adipose tissue (p<0.05). Adipose tissue organ culture treatment with epinephrine increased (p<0.05) PGC-1 alpha mRNA expression in both depots, but only epididymal adipose responded to a supra-physiological dose. Beta blockade attenuated the effects of an acute bout of exercise on PGC-1 alpha mRNA expression in epididymal, but not in retroperitoneal adipose tissue. This is the first study to demonstrate that rat white adipose tissue PGC-1 alpha mRNA expression is increased by acute and chronic exercise and epinephrine. Increases in circulating catecholamine levels might be one potential mechanism mediating exercise induced increases in PGC-1 alpha mRNA expression in rat abdominal adipose tissue. / Nutrition and Metabolism

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:AEU.10048/422
Date11 1900
CreatorsSutherland, Lindsey
ContributorsWright, David (Agricultural, Food, and Nutritional Science), Field, Catherine (Agricultural, Food, and Nutritional Science), Brindley, David (Biochemistry), Dyck, David (Human Health and Nutritional Sciences)
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeThesis
Format640556 bytes, application/pdf
RelationSutherland, Lindsey et al. (2009). J Physiol 587(7):1607-1617.

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