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Population pharmacokinetic-pharmacodynamic modelling and optimal experimental design of Ro115-1240 in healthy subjects and stress urinary incontinence patients

Stress urinary incontinence (SUI) is a distressing condition characterised by urine leakage upon physical effort, coughing or sneezing and may affect up to half of adult women. Despite this there are no globally approved pharmacotherapies. A common approach is the targeting of lower urinary tract (LUT) α₁-adrenoceptors, which however can lead to unwanted increases in blood pressure and reflex bradycardia.

Identiferoai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:493915
Date January 2008
CreatorsMajid, Oneeb
PublisherUniversity of Manchester
Source SetsEthos UK
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation

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