C-Myb is a DNA-binding transcription factor that functions in apoptosis, proliferation and differentiation. The role of c-Myb in vascular injury has been investigated in vitro and in vivo. Knock-down of c-Myb leads to a reduction in proliferation and an increase in apoptosis in vascular smooth muscle cells (VSMCs). Reduction of c-Myb activity has also been shown to reduce the incidence of neointimal formation in vivo by reducing VSMC proliferation. In contrast, over-expression of c-Myb in vivo leads to increased survival rates in certain cell types. Despite these observations, c-Myb expression has not yet been investigated in atherosclerosis. The balance between apoptosis and proliferation is pivotal in the pathogenesis of the disease. The aim of this thesis w as to investigate c-Myb expression in atherosclerotic lesions in addition to elucidating possible mechanisms by which c-Myb functions in atherosclerosis.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:502268 |
| Date | January 2009 |
| Creators | Kelly Ann, Kelly Ann |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
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