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Endovascular photodynamic therapy for preventing post-angioplasty and in-stent restenosisPai, Mahesh Laxman January 2005 (has links)
Cardiovascular disease is the commonest cause of death in the western world and atherosclerosis is the commonest cause of cardiovascular disease. It is characterised by the deposition of intra-luminal plaque leading to arterial stenosis. Balloon angioplasty offers a minimally invasive method of dilating peripheral and coronary arterial stenosis. The results of angioplasty are improved by stenting. However, a significant percentage of these patients have restenosis of their arteries with clinical and resource implications. Restenosis is caused by neointimal hyperplasia (NIH) and negative remodelling the combined effects of which result in vessel re-narrowing. It has previously been shown in animal models that photodynamic therapy (PDT) reduces the restenosis when used as an adjuvant to angioplasty. PDT involves the interaction of light at a particular wavelength with a pre-administered photosensitive agent to produce cell death by apoptosis in the presence of oxygen. The aims of this thesis are two fold. 1. to optimise the effects of PDT in preventing in-stent restenosis 2. to conduct a randomised controlled trial to show the clinical benefits of PDT in preventing post-angioplasty restenosis.
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Development of recombinant adeno-associated virus and second generation adenovirus vectors for the gene transfer of human apolipoprotein E (ApoE) in the APOE deficient mouseHarris, Julian David January 2005 (has links)
No description available.
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The role of matrix metalloproteinases in an animal model of atherosclerotic plaque ruptureJohnson, Jason Lee January 2005 (has links)
No description available.
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An investigation of gene and protein expression in carotid plaquesElasbali, Abdulbaset January 2006 (has links)
No description available.
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Mechanisms involved in the role of chylomicron remnants in the induction of lipid accumulation in THP-1 macrophagesMoore, Elizabeth Helen January 2005 (has links)
No description available.
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Endothelial dysfunction in atherosclerosisKharbanda, Rajesh Kumar January 2003 (has links)
No description available.
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Mechanism of arterial neointima formation : study of the effects of angiogenic factors in vivoKhurana, Rohit January 2004 (has links)
No description available.
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The identification of novel genes involved in atherosclerotic plaque instability using a whole-transcriptome approachPapaspyridonos, Marianna January 2005 (has links)
No description available.
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A study of the impacts of expression and genetic variation of matrix metalloproteinases on atherosclerosisMorgan, Angharad R. January 2004 (has links)
No description available.
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A study of the relationships between ABCA I gene polymorphisms, plasma lipid levels and risk of atherosclerosisBogari, Neda Mustafa January 2007 (has links)
No description available.
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