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Convenient Preparation of 2,7,8-Trimethyl-6-Hydroxychroman-2-Carboxylic Acid (γ-Trolox)

The title chroman is useful in synthesis and as a water-soluble analog of γ-tocopherol, a member of the vitamin E family. This new synthesis of γ-trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8-tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-18742
Date01 January 2008
CreatorsHyatt, John
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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