Since overweight and obesity reached pandemic proportions, the understanding of underlying causes became a complex research area. Within this context, the white adipose tissue acts as an endocrine organ, producing adipokines. Investigations of adipokines, their molecular structure, physiological impact and pro- or anti-inflammatory functions are in focus of attention to identify their metabolic role in mediating obesity induced metabolic modifications. Therefore, this work analyzed whether 14 different adipokines correlate with diverse eating behavior types and individual BMI values and how this associations are possibly mediated by these eating behavior phenotypes. Therefore, 557 participants of the Sorbs and 3101 participants of LIFE Leipzig Adult completed the German version of the Three-Factor-Eating Questionnaire to assess the eating behavior types “restraint”, “disinhibition” and “hunger”. Serum levels of 14 adipokines, including adiponectin, adipocyte fatty acid binding protein (AFABP), angiopoietin-related growth factor (AGF), chemerin, fibroblast growth factor (FGF)-19, FGF-21, FGF-23, insulin-like growth factor (IGF)-1, interleukin (IL) 10, irisin, progranulin, vaspin, pro-neurotensin (pro-NT) and pro-enkephalin (PENK) were measured. Based on significant correlations between the following adipokines: PENK, pro-NT, adiponectin, FGF-19, FGF-21, IGF-1, chemerin, progranulin, AGF and AFABP with different eating behavior items and BMI, mediation analyses were constructed, including the eating behavior item as mediation variable. Here, positive associations between chemerin, AFABP or leptin and BMI in Sorbian women was mediated by higher restraint or disinhibited eating, respectively. Additionally, in Sorbian women, the negative relation between IGF-1 and BMI was mediated by higher disinhibition and the positive link between AGF and BMI by lower disinhibition. In Sorbian men, the negative relationship between PENK and BMI was mediated by lower disinhibition and hunger, whereas the negative relation between IGF-1 and BMI was mediated by higher hunger. In the LIFE-Adult women ́s cohort, associations between chemerin and BMI were mediated by decreased hunger or disinhibition, respectively, whereas relations between PENK and BMI were fully mediated by decreased disinhibition.
In summary, this work provides evidence, that the adipokines PENK, IGF-1, chemerin, AGF, AFABP and leptin may impact the development of obesity by directly modifying individual eating behavior.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:80943 |
| Date | 30 September 2022 |
| Creators | Würfel, Marleen |
| Contributors | Universität Leipzig |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:doctoralThesis, info:eu-repo/semantics/doctoralThesis, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
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