Yes / Neuronal activity regulates the transcription and
translation of the immediate-early gene Arc/Arg3.1,
a key mediator of synaptic plasticity. Proteasomedependent
degradation of Arc tightly limits its
temporal expression, yet the significance of this
regulation remains unknown. We disrupted the temporal
control of Arc degradation by creating an Arc
knockin mouse (ArcKR) where the predominant Arc
ubiquitination sites were mutated. ArcKR mice had
intact spatial learning but showed specific deficits
in selecting an optimal strategy during reversal
learning. This cognitive inflexibility was coupled to
changes in Arc mRNA and protein expression resulting
in a reduced threshold to induce mGluR-LTD and
enhanced mGluR-LTD amplitude. These findings
show that the abnormal persistence of Arc protein
limits the dynamic range of Arc signaling pathways
specifically during reversal learning. Our work
illuminates how the precise temporal control of activity-dependent
molecules, such as Arc, regulates synaptic
plasticity and is crucial for cognition. / Open access funded by Biotechnology and Biological Sciences Research Council
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/16201 |
| Date | 2018 May 1931 |
| Creators | Wall, M.J., Collins, D.R., Chery, S.L., Allen, Z.D., Pastuzyn, E.D., George, A.J., Nikolova, V.D., Moy, S.S., Philpot, B.D., Shepherd, J.D., Muller, Jurgen, Ehlers, M.D., Mabb, A.M., Corrêa, Sonia A.L. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | ©2018 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)., CC-BY |
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