Immunosuppressive protocol with delayed use of low-dose tacrolimus after aortic transplantation suppresses donor-specific anti-MHC class I and class II antibody production in rats

Description

Background: Arterial allografts are used as vascular conduits in the treatment of prosthetic graft infection. Immunosuppression
decreases their rupture risk rate. However, immunosuppression can be unprofitable in florid infection. Previously, we confirmed inhibition of cell-mediated destruction of rat aortic grafts by delayed use of tacrolimus. In this work, we studied the influence of this protocol on the antibody-mediated rejection.

Links & Downloads

1. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-167365
2. urn:nbn:de:bsz:15-qucosa-167365
3. issn:1425-9524
4. http://www.qucosa.de/fileadmin/data/qucosa/documents/16736/OAP-2015-011_Matia_889870.pdf

Tags

Antikörpervermittelte Abstoßung

arterielle Allotransplantate

Tacrolimus

Antibody-mediated rejection

arterial allografts

tacrolimus

Anti-MHC class I antibody

Anti-MHC class II antibody

arterial rejection

ddc:610

Additional Fields

Identifer	oai:union.ndltd.org:DRESDEN/oai:qucosa.de:bsz:15-qucosa-167365
Date	12 May 2014
Creators	Matia, Ivan, Fellmer, Peter, Splith, Katrin, Varga, Martin, Adamec, Milos, Kämmerer, Ines, Feldbrügge, Linda, Krenzien, Felix, Hau, Hans-Michael, Atanasov, Georgi, Schmelzle, Moritz, Jonas, Sven
Contributors	Universitätsklinikum Leipzig, Klinik für Viszeral-, Transplantations-, Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig, Translationszentrum für Regenerative Medizin, Institute for Clinical and Experimental Medicine, Transplant Surgery Department, Annals of transplantation,
Publisher	Universitätsbibliothek Leipzig
Source Sets	Hochschulschriftenserver (HSSS) der SLUB Dresden
Language	English
Detected Language	English
Type	doc-type:article
Format	application/pdf
Source	Annals of transplantation 2014, 19:225-232