Indiana University-Purdue University Indianapolis (IUPUI) / Erosive tooth wear (ETW) is a growing dental condition often associated with
aging. This in-vitro project comprised three studies aiming to investigate the impact of
tooth age on ETW susceptibility and prevention. In the first study, un-identified extracted
premolars were collected and had their ages estimated using validated dental forensic
methods. The premolars were examined to investigate the relationship between age and
presence and severity of ETW, as well as other main dental-hard tissues conditions. ETW,
dental caries, fluorosis, extrinsic staining and tooth color were evaluated using
established clinical indices. In the second study, the tooth age impact on ETW
susceptibility and response to preventive treatments (Sn+F, NaF, and de-ionized water
control) were evaluated using representative samples from the initial study. Enamel and
dentin specimens were prepared and subjected to daily erosion-treatmentremineralization
cycling procedure. Surface loss (SL) was determined during and after
the cycling, by optical profilometry. Similar protocol was adopted in the third study with
the addition of toothbrushing abrasion to the model, in order to explore the interplay
between age and toothpaste abrasivity on erosion-abrasion development. SL was
measured during and after the erosion-toothbrushing-remineralization cycling. The
relationships between age and the investigated variables were assessed using linear
regression models. In conclusion: 1. The presence and severity of ETW, dental caries,
and extrinsic staining increased with age, while of enamel fluorosis decreased. Tooth also
showed to be darker with age. 2. Susceptibility of enamel and dentin to demineralization increased with age. Sn+F showed the highest anti-erosive efficacy, and was not affected
by age. NaF showed lower efficacy on dentin, which increased with age. 3. Enamel and
dentin SL increased with toothpaste abrasivity level. Dentin SL also increased with age.
Age effect on enamel SL was observed only with low abrasive toothpaste. Age-related
changes on enamel and dentin affected ETW development. / 2020-05-17
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/16265 |
| Date | January 2018 |
| Creators | Algarni, Amnah Abdullah |
| Contributors | Hara, Anderson T., Lippert, Frank, Platt, Jeffrey A., González-Cabezas, Carlos, Ungar, Peter |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Dissertation |
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