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The evolution of RNA and the actin protein family

In my dissertation I have broadly studied the evolution of RNA as well as the phylogenetic history of the actin protein family. In the first chapter I examined how various evolutionary processes interact at high mutation rates, which led to simple prediction based on the strength of selection. In the second chapter, I tested mRNA secondary structure stability at the beginning of genes as a way of identifying whether putative genes might be functional or not. Finally, I reconstructed the phylogenetic history of the actin protein family in vertebrates, revealing that a novel isoform is actively evolving in contrast to the remaining protein isoforms.

Identiferoai:union.ndltd.org:UTEXAS/oai:repositories.lib.utexas.edu:2152/30391
Date20 August 2015
CreatorsKeller, Thomas E.
ContributorsBull, James J., Wilke, C. (Claus)
Source SetsUniversity of Texas
Detected LanguageEnglish
TypeThesis
Formatapplication/pdf

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