Despite great progress of lab-on-a-chip (LoC) technology platforms in the last 30 years, there is a lack of standardized microfluidic components, real on-chip utomation and progressive functional scalability of the fluidic circuits. Hydrogel-based microfluidic circuits have a high scaling potential and provide on-chip automation, but are complex in system design. An advanced circuit concept for planar microfluidic chip architectures, originating from the early era of the semiconductor-based resistor-transistor-logic (RTL) is presented and the hydrogel-based chemical volume phase transition transistor (CVPT) for logic gate operations is implemented. The circuit concept (CVPT-RTL) is robust and simple in design, feasible with common materials and manufacturing techniques of the LoC technology. Thereby, three major challenges are solved: contamination issues, maintaining the signal compliance for cascadability, and chemical signal inversion. As a central element, a CVPT cascode is introduced. The functionality of the concept is verified by a 24 h test of the NAND gate operation and a self-automated chemofluidic analog-to-digital converter, utilized as interface between bioreactors and extended microfluidic logic circuits. Moreover, the CVPT-RTL cascode demonstrates the expected selfstabilizing performance of the NAND gate. Accompanying simulations of the component behavior based on a network description implemented in Matlab Simscape match with the experimental results.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:88392 |
| Date | 22 February 2024 |
| Creators | Beck, Anthony, Mehner, Philipp Jan, Voigt, Andreas, Obst, Franziska, Marschner, Uwe, Richter, Andreas |
| Publisher | Wiley-VCH GmbH |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2365-709X, 10.1002/admt.202200185, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Graduiertekolleg/211944370//GRK 1865: Hydrogel-basierte Mikrosysteme |
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