Renal tubules represent an intercellular unit and function as a syncytium. When acute tubular necrosis was first visualized to occur through a process of synchronized regulated necrosis (SRN) in handpicked primary renal tubules, it became obvious that SRN actually promotes nephron loss. This realization adds to our current understanding of acute kidney injury (AKI)-chronic kidney disease (CKD) transition and argues for the prevention of AKI episodes to prevent CKD progression. Because SRN is triggered by necroptosis and executed by ferroptosis, 2 recently identified signaling pathways of regulated necrosis, a combination therapy employing necrostatins and ferrostatins may be beneficial for protection against nephron loss. Clinical trials in AKI and during the process of kidney transplantation are now required to prevent SRN. Additionally, necrotic cell death drives autoimmunity and necroinflammation and therefore represents a therapeutic target even for the prevention of antibody-mediated rejection of allografts years after the transplantation process.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:71624 |
| Date | 04 August 2020 |
| Creators | Mässenhausen, Anne von, Tonnus, Wulf, Linkermann, Andreas |
| Publisher | Karger |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1660-2110, 10.1159/000490807, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Medical Clinic 3 an der Technischen Universität Dresden/314061271//Die Nebenniere: Zentrales Relais in Gesundheit und Krankheit/SFB-TRR 205, info:eu-repo/grantAgreement/Deutsche Forschungsgemeinschaft/Medical Clinic 3 an der Technischen Universität Dresden/213602983// Biologie der xenogenen Zell- und Organtransplantation - vom Labor in die Klinik/SFB-TRR 127 |
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