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Previous issue date: 2011-02-24 / Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico / The balance between the expression of matrix metalloproteinases (MMPs) and their
tissue inhibitors (TIMPs) has been related to various physiological and pathological
processes, including salivary gland morphogenesis and tumor invasion and metastasis
processes. Pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) respectively
represent benign and malignant neoplasias of salivary glands. Although they share the same
cell origin, they present distinct biological behavior. The aim of this study was to compare the
immunohistochemical expression of MMPs -2, -7, -9 and -26, and of TIMPs -1 and -2, in
cases of PA and ACC of minor salivary glands. Twenty cases of PA and twenty cases of ACC
were assessed according to the presence, intensity and location of MMPs and TIMPs in the
tumor parenchyma. Most of the PAs and ACCs presented a high expression of MMP -2, -7, -9
and -26 and of TIMP -1 and -2, predominantly located in tumor cells. There was no
significant difference in the expression of MMPs -2 (p=0.359), -7 (p=0.081) and -26
(p=0.553), as well as of TIMPs -1 (p=0.657) and -2 (p=0.248), between the parenchyma of
PAs and ACCs. However, MMP-9 showed a significant difference of expression between the
two tumors, with the ACC showing more intense marking for this gelatinase (p=0.041). The
strong expression of MMP-9 observed in the parenchyma suggests that this gelatinase may
play an important role in the biological behavior of these tumors. On the other hand, although
there was no significant difference between the marking of MMP -2, 7 and 26 in the studied
tumors, the data, when analyzed as a whole, suggest that these proteases may take part in the
process of tissue remodeling in both tumors, but do not present a direct relation with the
pattern of aggressiveness of ACC. Nonetheless, matrilisins may indirectly influence the
behavior of this tumor due to their capacity of activating MMP-9, strongly expressed in the
parenchyma of ACC / O balan?o entre a express?o das metaloproteinases da matriz (MMPs) e seus inibidores
teciduais (TIMPs) tem sido relacionado a v?rios processos fisiol?gicos e patol?gicos,
incluindo a morfog?nese de gl?ndulas salivares e os processos de invas?o e met?stase
tumoral. O adenoma pleom?rfico (AP) e o carcinoma aden?ide c?stico (CAC) representam,
respectivamente, neoplasias benignas e malignas de gl?ndulas salivares que, embora
compartilhem a mesma origem celular, apresentam comportamentos biol?gicos distintos. O
prop?sito deste estudo foi comparar a express?o imuno-histoqu?mica das MMPs -2, -7, -9 e -
26 e dos TIMPs -1 e -2 em casos de AP e CAC de gl?ndulas salivares menores. Vinte casos
de AP e vinte casos de CAC foram avaliados quanto ? presen?a, intensidade e localiza??o das
MMPs e TIMPs no par?nquima tumoral. A maioria dos APs e CACs apresentaram alta
express?o das MMPs e dos TIMPs, predominantemente localizada nas c?lulas tumorais. N?o
houve diferen?a estatisticamente significativa na express?o das MMPs -2 (p=0,359), -7
(p=0,081) e -26 (p=0,553), bem como dos TIMPs -1 (p=0,657) e -2 (p=0,248), entre o
par?nquima dos APs e CACs. A MMP-9 demonstrou uma diferen?a significativa de express?o
entre os dois tumores, apresentando o CAC uma marca??o mais intensa para esta gelatinase
(p=0,041). A forte express?o da MMP-9 observada no par?nquima dos CACs sugere que esta
gelatinase possa desempenhar um papel importante no comportamento biol?gico destes
tumores. Por outro lado, apesar de n?o ocorrer uma diferen?a significativa entre as m?dias das
MMPs -2, 7 e 26 nos tumores estudados, os dados quando analisados em conjunto sugerem
que estas proteases podem estar participando de processos de remodela??o tecidual em ambos
os tumores, mas n?o apresentam uma rela??o direta com o padr?o de agressividade do CAC.
Entretanto, as matrilisinas poderiam influenciar indiretamente o comportamento deste tumor
devido a sua capacidade de ativar a MMP-9, fortemente expressa no par?nquima destes
tumores
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17149 |
| Date | 24 February 2011 |
| Creators | Freitas, Val?ria Souza |
| Contributors | http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4787927Z7&dataRevisao=null, Santos, Jean Nunes dos, CPF:62627673487, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4728907T1, Bento, Patr?cia Meira, CPF:48698024491, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4776885U7&dataRevisao=null, Freitas, Roseana de Almeida, CPF:28444361453, http://lattes.cnpq.br/9512014003639405, Souza, L?lia Batista de |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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