White adipose tissue (WAT) is a metabolic organ with flexibility to retract and expand based
on energy storage and utilization needs, processes that are driven via the coordination of different
cells within adipose tissue. WAT is comprised of mature adipocytes (MA) and cells of the stromal
vascular cell fraction (SVF), which include adipose progenitor cells (APCs), adipose endothelial cells
(AEC) and infiltrating immune cells. APCs have the ability to proliferate and undergo adipogenesis to
form MA, the main constituents ofWAT being predominantly composed of white, triglyceride-storing
adipocytes with unilocular lipid droplets. While adiposity and adipose tissue health are controlled
by diet and aging, the endogenous circadian (24-h) biological clock of the body is highly active in
adipose tissue, from adipocyte progenitor cells to mature adipocytes, and may play a unique role in
adipose tissue health and function. To some extent, 24-h rhythms in adipose tissue rely on rhythmic
energy intake, but individual circadian clock proteins are also thought to be important for healthy
fat. Here we discuss how and why the clock might be so important in this metabolic depot, and how
temporal and qualitative aspects of energy intake play important roles in maintaining healthy fat
throughout aging.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:86983 |
| Date | 31 August 2023 |
| Creators | Ribas-Latre, Aleix, Eckel-Mahan, Kristin |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 2084, 10.3390/nu14102084 |
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