Submitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2017-07-26T14:34:03Z
No. of bitstreams: 1
2012 - Elaine Concei??o Liporage de Mendon?a.pdf: 3515906 bytes, checksum: ebf489151f2cd6961ddeeb292cd910a7 (MD5) / Made available in DSpace on 2017-07-26T14:34:03Z (GMT). No. of bitstreams: 1
2012 - Elaine Concei??o Liporage de Mendon?a.pdf: 3515906 bytes, checksum: ebf489151f2cd6961ddeeb292cd910a7 (MD5)
Previous issue date: 2012-03-16 / Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES / The use of antibiotic in the control of intramammary infections and in the elimination of
its possible sources in dairy farms is an important control measure. However, the
inappropriate use of antibiotics can result in the appearance of resistant strains and
compromise the efficiency of the treatment. Besides Staphylococcus spp. are among the
main pathogens of bovine mastitis, they are often resistant to antibiotics, especially
beta-lactamics, mainly by two distinct mechanisms: the production of extracellular
enzyme beta-lactamase, encoded by the blaZ gene, and production of PBP2a or PBP2 '
a penicillin-binding protein with low affinity, encoded by the mecA gene. The
expression of mecA gene is constitutive or induced by beta-lactamic antibiotics, such as
oxacillin and cefoxitin. The mecA gene is inserted into the chromosome through a
staphylococcal mobile genetic element, called staphylococcal cassette chromosome mec
(SCCmec). The present study evaluated the phenogenotypical resistance profile to betalactam
antibiotics of 250 Staphylococcus spp. isolates, using oxacillin and cefoxitin as
markers in order to produce data to the knowledge of resistance in dairy farms located
in the South-Fluminense and the Metropolitan regions of the State of Rio de Janeiro to
support the implementation of measures to control this disease. The assessment of
resistance was made through 8 different phenotypic tests and yielded 54 profiles. Disk
diffusion and agar screen with oxacillin were used as "gold standard" for the calculation
of sensitivity, specificity and prediction once they are recommended by the CLSI
veterinarian as standardized tests. Disk diffusion with cefoxitin achieved the best
performance in the prediction of oxacillin resistance. Genotypic detection of mecA do
not provided any positive isolate, otherwise mecI and mecRI genes were also detected in
11.6% (29/250) of the studied Staphylococcus spp. Four cassette mec types were
detected (I, II, III and IV), being type I the most disseminated one. Gene blaZ was
detected in 5.2% (13/250) isolates. From these 13 blaZ positive isolates, the whole
system comprising blaR1-blaI-blaZ was detected in 23.1% (3/13) isolates / MENDON?A, Elaine Concei??o Liporage. Caracteriza??o fenogenot?pica da
resist?ncia antimicrobiana em Staphylococcus spp. isolados de mastites cl?nicas e
subcl?nicas em unidades leiteiras de munic?pios do Rio de Janeiro como subs?dio
para implementa??o de medidas de controle. 89 p. Disserta??o (Mestrado em
Ci?ncias Veterin?rias). Instituto de Veterin?ria, Departamento de Parasitologia Animal,
Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2012.
A utiliza??o de antibi?ticos no controle das infec??es intramam?rias e na elimina??o de
prov?veis fontes de infec??o nas fazendas leiteiras se constitui em importante medida de
controle. No entanto, o uso inadequado de antibi?ticos no tratamento da doen?a pode
gerar o aparecimento de cepas resistentes e comprometer a efici?ncia do tratamento.
Bact?rias do g?nero Staphylococcus spp. est?o entre os principais agentes etiol?gicos da
mastite bovina e s?o freq?entemente resistentes aos antimicrobianos, em especial aos
beta-lact?micos, principalmente por dois mecanismos distintos: a produ??o da enzima
extracelular beta-lactamase, codificada pelo gene blaZ, e a produ??o de PBP2a ou
PBP2?, uma prote?na ligante de penicilina de baixa afinidade, codificada pelo gene
mecA. A express?o do gene mecA ? constitutiva ou induzida por antibi?ticos
betalact?micos, como a oxacilina e cefoxitina. O gene mecA est? inserido no
cromossomo estafiloc?cico atrav?s de um elemento gen?tico m?vel, denominado
cassete estafiloc?cico cromoss?mico mec (SCCmec). O presente estudo avaliou o perfil
fenogenot?pico de resist?ncia aos beta-lact?micos em 250 isolados de Staphylococcus
spp, utilizando os marcadores oxacilina e cefoxitina, de modo a produzir dados que
possam contribuir para o conhecimento da resist?ncia antimicrobiana em algumas
propriedades leiteiras das regi?es Sul-Fluminense e Metropolitana do Estado do Rio de
Janeiro com o objetivo de subsidiar a implementa??o de medidas de controle dessa
enfermidade. A avalia??o da resist?ncia foi feita a partir de 8 diferentes testes
fenot?picos, sendo obtidos 54 perfis. Os testes de difus?o em disco simples e ?gar screen
com oxacilina foram utilizados como ?padr?o ouro? para os c?lculos dos valores de
sensibilidade, especificidade e predi??o por serem preconizados pelo CLSI veterin?rio.
O teste de difus?o em disco simples com cefoxitina foi o de melhor desempenho na
predi??o da resist?ncia a oxacilina. Na avalia??o genot?pica, n?o foi detectado qualquer
isolado positivo para o gene mecA, j? os genes mecI e mecRI foram detectados
igualmente em 11,6% (29/250) dos Staphylococcus spp avaliados. Foram detectados os
quatro tipos de cassete mec analisados (I, II, III e IV), sendo o tipo I o que teve mais
ampla distribui??o entre as regi?es estudadas. Gene blaZ foi detectado em 5,2%
(13/250) dos isolados, sendo que nestes, todo o sistema blaZ-blaI- blaR1 foi detectado
em 23,1% (3/13) dos isolados.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:jspui/1916 |
| Date | 16 March 2012 |
| Creators | Mendon?a, Elaine Concei??o Liporage de |
| Contributors | Souza, Miliane Moreira Soares de, Coelho, Shana de Mattos de Oliveira, Senna, Jos? Proc?pio Moreno, Nascimento, Elmiro Rosendo do |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Programa de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Instituto de Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | AARESTRUP, F. M. Comparative ribotyping of Staphylococcus intermedius isolated from members of the Canidea gives possible evidence for hostspecificity and co-evolution of bacteria and hosts. International Journal Systematic and Evolutionary Microbiology, v. 51, p. 1343?1347, 2001. ADAMS, H. R. Farmacologia e Terap?utica em Veterin?ria. 8.ed. Rio de Janeiro: Guanabara Koogan, 2003, 1033p. AMARAL, L. A.; ROSSI J?NIOR, O. D.; NADER FILHO, A.; FERREIRA, F.L.A. & BARROS, L. S. S. Incidence of Staphylococcus sp. in the water used by dairy farms in the State of S?o Paulo. Arquivo Brasileiro de Medicina Veterin?ria Zootecnia, Belo Horizonte, v. 55, n. 5, p. 14884-900, oct. 2003. ANDRADE, M. A.; DIAS FILHO, F. C.; MESQUISTA, A. J. & ROCHA, P. T. Sensibilidade ?in vitro? de Staphylococcus aureus isolados de amostras de leite de vacas com mastite subcl?nica. Ci?ncia Animal Brasileira, v.1 n.1 p.53-57, 2000. BANNERMAN, T.M. Staphylococcus, Micrococcus and other catalase-positive cocci that grow aerobically. In: P. R. Murray (Ed.). Manual of Clinical Microbiology, Eighth Edition. Washington, DC: ASM Press, v. 1, p. 384-404, 2003. BANNOEHR, J.; BEN ZAKOUR, N. L.; WALLER, A. S.; GUARDABASSI, L.; THODAY, K. L.; VAN DEN BROEK, A. H. AND FITZGERALD, J. R. Population genetic structure of the Staphylococcus intermedius group: insights into agr diversification and the emergence of methicillin-resistant strains. Journal of Bacteriology. n. 189, p. 8685?8692, 2007. BANNOEHR, J.; FRANCO, A.; IURESCIA, M.; BATTISTI, A. & FITZGERALD, J. R. Molecular Diagnostic Identification of Staphylococcus pseudintermedius. Journal of Clinical Microbiology, v. 47, n. 2, p. 469-471, 2009. BARBERIO, A.; GIETL, H. & DALVIT, P. ?In vitro? sensibilidade aos antimicrobianos de Staphylococcus aureus e coliformes isolados de mastite bovina na regi?o de Veneto, It?lia, no per?odo de 1996-1999. Napgama, v. 5, n. 1, p. 10, 2002. BAREILLE N., BEAUDEAU F., BILLION S., ROBERT A. & FAVERDIN P. Effects of health disorders on feed intake and milk production in dairy cows. Livestock Production Science, n. 83, p. 53-62, 2003. BEAUDEAU F., FOURICHON C., SEEGERS H. & BAREILLE N. Risk of clinical mastitis in dairy herds with a high proportion of low individual milk somatic-cell counts. Preventive Veterinary Medicine, n. 53, p. 43-54, 2002. BES, V.; GUERIN-FAUBLEE, H.; MEUGNIER, J.; ETIENNE & FRENEY, J. Improvement of the identification of staphylococci isolated from bovine mammary infections using molecular methods. Veterinary Microbiology, v.71, p. 287?294, 2000. BLACK, J. G. Microbiologia: Fundamentos e Perspectivas. 4? ed., Rio de Janeiro: Guanabara Koogan, p. 370-419, 2002. 48 BLONDEAU, J. M.; HANSEN, G.; BORSOS, S.; IRVINE, L. & BLANCO, L. In vitro susceptibility of 4903 bacterial isolates of gemifloxcin - an advanced fluoroquinolone. International Journal Antimicrobial Agents, v. 9, p. 44-49, 2003. BOOTH, N., McDONALD, L.E. Farmacologia e terap?utica em veterin?ria. Rio de Janeiro: Guanabara Koogan, 1992. 997 p. BOYLE-VAVRA, S. & DAUM, R. S. Community-acquired methicillin resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin. Labolatory Invetigation Journal , n. 87, p. 3-9, 2007. BRADLEY, A. J. Bovine mastitis: an evolving disease. Veterinary Journal, n. 164, p. 116- 128, 2002.. BRASIL. SECRETARIA DE VIGIL?NCIA SANIT?RIA. Portaria n? 490. Institui Grupo de Trabalho para concluir os estudos de avalia??o de risco ? sa?de humana decorrente do uso da Avoparcina na ?rea veterin?ria, integrado por especialistas representantes dos ?rg?os e entidades relacionados. Di?rio Oficial da Uni?o, 30 jun. 1998 (a). BRASIL. MINIST?RIO DA SA?DE. Secretaria de Vigil?ncia Sanit?ria. Portaria n? 819. D? conhecimento p?blico ?s conclus?es do Grupo de Trabalho sobre a Avoparcina. Di?rio Oficial da Uni?o, 19 out 1998 (b). BRASIL. AG?NCIA NACIONAL DE VIGIL?NCIA SANIT?RIA. Resolu??o RDC n? 5. Cria Grupo de Trabalho sobre Medicamentos Veterin?rios em Alimentos. Di?rio Oficial da Uni?o, 2000. BRASIL. MINIST?RIO DA AGRICULTURA, PECU?RIA E ABASTECIMENTO. Instru??o Normativa n? 38. Pro?be a fabrica??o, a importa??o e a comercializa??o de cloranfenicol, de nitrofuranos e de produtos que contenham estes princ?pios ativos, para uso em prepara??es de insumos utilizados na pecu?ria nacional. Di?rio Oficial da Uni?o, 9 maio 2002. BRASIL. MINIST?RIO DA AGRICULTURA, PECU?RIA E ABASTECIMENTO. Instru??o Normativa n? 27. Adota o Regulamento T?cnico Mercosul sobre crit?rios para defini??o de prioridades aos Programas de Controle de Res?duos de Drogas Veterin?rias em Produtos de Origem Animal destinados ao consumo humano. Di?rio Oficial da Uni?o, 30 jun 2003 (a). BRASIL. AG?NCIA NACIONAL DE VIGIL?NCIA SANIT?RIA. Resolu??o RDC n? 253. Cria o Programa de An?lise de Res?duos de Medicamentos Veterin?rios em Alimentos de Origem Animal ? PAMVet. Di?rio Oficial da Uni?o, 18 set. 2003 (b). BRASIL. MINIST?RIO DA AGRICULTURA, PECU?RIA E ABASTECIMENTO. Instru??o Normativa n? 13. Aprova o Regulamento T?cnico sobre Aditivos para Produtos Destinados ? Alimenta??o Animal, segundo as boas pr?ticas de fabrica??o, contendo os procedimentos sobre avalia??o da seguran?a de uso, registro e comercializa??o. Di?rio Oficial da Uni?o, 01 dez 2004. 49 BRITO, M. A. V. P.; BRITO, J. R. F.; RIBEIRO, M. T. & VEIGA, V. M. O. Padr?o de infec??o intramam?ria em rebanhos leiteiros: exame de todos os quartos mam?rios das vacas em lacta??o. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, Juiz de Fora, v. 51, n. 2, p.129-135, 2000. BRITO, M. A. V. P.; BRITO, J. R. F.; SILVA, M. A. S. & CARMO, R. A. Concentra??o m?nima inibit?ria de dez antimicrobianos para amostras de S. aureus isoladas de infec??o intramam?ria bovina. Arquivo Brasileiros de Medicina Veterin?rio e Zootecnia, v. 53, n. 5, p.10-17, 2001. BRITO, M. A.; BRITO, V. P.; RIBEIRO, M. T. & VEIGA, V. M. O. Padr?o de infec??o de intramam?ria em rebanhos leiteiros: Exame de todos os quartos mam?rios das vacas em lacta??o. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v. 51, p. 129?135, 2002. BURTON, J. L. & ERSKINE, R. J. The Veterinary Clinics - Food Animal Practice, v. 19, p. 1-45, 2003. BUSATO, A.; TRACHSEL, P.; SCHALLIBAUM, M. & BLUM, J. W. Udder health and risk factors for subclinical mastitis in organic dairy farms in Switzerland. Preventive Veterinary Medicine, n. 44, p. 205-220, 2000. BUZZOLA, F. R.; QUELLE, L.; GOMEZ, M. I.; CATALANO, M.; STEELE-MOORE, L.; BERG, D.; GENTILINI, E.; DENAMIEL, G. & SORDELLI, D. O. Genotypic analysis of Staphylococcus aureus from milk of dairy cows with mastitis in Argentina. Epidemiology & Infecion, v. 126 p. 445-452, 2001. CARDOSO, H. F. T.; CARMO, L. S.; SILVA, N. & SENA, M. J. Production of enterotoxins and toxic shock syndrome toxin by Staphylococcus aureus isolated from bovine mastitis in Brazil. Letters in Applied Microbiology, Oxford, n. 29, p. 347-349, 2000. CAUWELIER, B.; GORDTS, B. & DESCHEEMAECKER, P. Evaluation of a disk diffusion method with cefoxitin (30?g) for detection of methicillin-resistant Staphylococcus aureus. European Journal Microbiology Infections Disease, v. 23, p. 389-392, 2004. CHAMBERS, H. F. Methicillin resistance in staphylococci: molecular and biochemical basis and clinical implications. Revista Clinical Microbiology, v. 10, n. 4, p. 781-791, 1997. CHAMBERS, H. F. Penicillin ? Binding Protein ? Mediated Resistance in Pneumococci and Staphylococci. Journal of Infectious Diseases, v. 179, n. 2, p. 353-359, 1999. CHOPRA, I. & ROBERTS, M. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiology Molecular Biology Review, v. 65, n. 2, p. 232-260, 2001. CLARKE, S. R. & DYKE, K. G. H. The signal transducer (BlaRI) and the repressor (BlaI) of the Staphylococcus aureus ?-lactamase operon are inducible. Microbiology, v. 147, p. 803- 810, 2001. 50 CLSI. Performance Standards for Antimicrobial Disk and Diluition Susceptibility Tests for Bacteria Isolated From Animals; Approved Standards-Third Edition, M31-A3. CLSI, Wayne, PA: Clinical and Laboratory Standards Institute, 2008. CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 20th Informational Supplement, M100-S20. CLSI, Wayne, PA Clinical and Laboratory Standards Institute, 2011. COHEN, P. R. Community-acquired methicillin resistant Staphylococcus aureus skin infections: a review of epidemiology, clinical features, management and prevention. International Journal of Dermatology, v. 46, p. 1-11, 2007. COELHO, S. M. O.; MENEZES, R. A.; SOARES, L. C.; PEREIRA, I. A.; GOMES, L. P. & SOUZA, M. M. S. Mapeamento do Perfil de Resist?ncia e Detec??o do gene mecA em Staphylococcus aureus e Staphylococcus intermedius oxacilina-resistentes isolados de esp?cies humanas e animais. Revista Ci?ncia Rural, v. 37, p. 195-200, 2007. COELHO, S. M. O.; REINOSO, E.; PEREIRA, I. A.; SOARES, L. C.; DEMO, M.; BOGNI, C. & SOUZA, M. M. S. Virulence factors and antimicrobial resistance of Staphylococcus aureus isolated from bovine mastitis in Rio de Janeiro. Revista Pesquisa Veterin?ria Brasileira, v. 29, p. 369-374, 2009. CORR?A, I. Resist?ncia a drogas antimicrobianas de cepas de Staphylococcus coagulase positiva de leite mast?tico bovino. Jaboticabal, Universidade Estadual Paulista J?lio de Mesquita Filho, 2003. 58p. COSTA, E. O.; RAIA, M. R.; WATANABE, E. T.; G ARINO, F.; COELHO, V. Infu?ncia do tratamento intramam?rio de casos de mastite de bovinos em lacta??o em rela??o ? presen?a de res?duos de antibi?ticos no leite de quartos sadios. Napgama, v.3 n.4 p.14-17, 2000. CULEBRAS, E.; RODRIGUEZ-AVIAL, I.; BETRIU, C.; REDONDO, M. & PICAZO, J.J. Macrolide and tetracycline resistance and molecular relationships of clinical strains of Streptococcus agalactiae. Antimicrobial Agents and Chemotherapy, v.46, n.5, p.1574? 1576, 2002. CUNHA, M. L. R. S; LOPES, R. S.; RUGOLO, C. A. M. & CHALITA, L. V. A. S. Clinical significance of coagulase-negative staphylococci isolated from neonates. Journal Antimicrobial and Chemotherapy, v. 48, p. 463?478, 2002. CUNY, C.; LAYER, F.; STROMMENGER, B. & WITTE, W. Rare Occurrence of Methicillin-Resistant Staphylococcus aureus CC130 with a Novel mecA Homologue in Humans in Germany. PLoS ONE,v. 6, n. 9, 2011. DANCER, S. J. The problem with cephalosporins. Journal of Antimicrobial and Chemotherapy, v. 48, p. 463?478, 2001. DAUM, R. S.; ITO, T.; HIRAMATSU, K.; HUSSAIN, F.; MONGKOLRATTANOTHAI, K., JAMKLANG, M. & BOYLE-VAVRA, S. A novel methicillin-resistance cassette in community-acquired methicillin-resistant Staphylococcus aureus isolates of diverse genetic backgrounds. Jornal of Infectious Disease, v. 186, p.1344-1347, 2002. 51 DEURENBERG, R. H. & STABBERINGH, E. E. The molecular evolution of hospital-and community-associated methicillin resistant Staphylococcus aureus. Current Molecular Medicine, v. 9, p. 100-115, 2009. DEVRIESE, L. A.; VANCANNEYT, M. & BAELE, M. Staphylococcus intermedius sp. nov., a coagulase positive species from animals. International Journal of Systematic and Evironmental Microbiology, v. 55, p. 1569-1573, 2005. DEVRIESE, L. A.; HERMANS, K.; BAELE, M. AND HAESEBROUCK, F. Staphylococcus pseudintermedius versus Staphylococcus intermedius. Veterinary Microbiology, v. 133, p. 206?207, 2008. DESCLOUX, S., ROSSANO, A. AND PERRETEN, V. Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius. Journal of Clinical Microbiology, v. 46, p. 1818?1823, 2008. DINGWELL, R. T.; LESLIE, K. E.; SCHUKKEN, Y. H.; SARGEANT, J. M.; TIMMS, L. L.; DUFFIELD, T. F.; KEEFE, G. P.; KELTON, D. F.; LISSEMORE, K. D. & CONKLIN, J. Association of cow and quarter-level factors at drying-off with new intramammary infections during the dry period. Preventive Veterinary Medicine, v. 63, p. 75-89, 2004. Donatele, D. M. & Motta, O. V. Folly MM. Perfil antimicrobiano de linhagens de Staphylococcus spp. coagulase positiva na mastite subcl?nica de vacas leiteiras nas regi?es norte e noroeste do Estado do Rio de Janeiro. Revista N?cleo de Apoio ? Pesquisa da Gl?ndula Mam?ria e Produ??o Leiteira, v. 5, p. 3-6, 2002. Empresa Brasileira de Pesquisa Agropecu?ria (EMBRAPA). Centro Nacional de Pesquisa de Gado de Leite, http://www.cnpgl.embrapa.br/. Acessado em: 4 de Janeiro de 2012. ERSKINE, R. 2000. Antimicrobial drug use in bovine mastitis. Pages 712?734 in Antimicrobial Therapy in Veterinary Medicine. J. F. Prescott, J. D. Baggot, and R. D. Walker, ed. Iowa State University Press, Ames. ERSKINE, R. J.; WALKER, R. D.; BOLIN, C. A.; BARTLETT, P. C. & WHITE, D. G. Trends in antibacterial susceptibility of mastitis pathogens during a sevenyear period. Journal of Dairy Science, v. 85, n. 5, p. 1111-1118, 2002. EUROPEAN COMMISSION. Commission Regulation (EC) No 2.788/1998. Amending Council Directive No 70/524/EEC concerning additives in feedingstuffs as regards the withdrawal of authorisation for certain growth promoters. Off. Journal European Communities, 23 dec. 1998;. FAO. Residues of some veterinary drugs in animals and foods. Report of the 60th meeting of the Joint FAO/WHO Expert Committee on Food Additives; 2003 Feb 6-12; Geneva; Switzerland. FAO Food and Nutrition Paper 41/15. Rome, 2004. 52 FAO/WHO. Joint FAO/WHO Expert Committee on Food Additives. 66th meeting (Residues of veterinary drugs). 2006 Feb 22-28; Rome; Italy. Summary and Conclusions. Rome, March 2006. FRAZIER, W. C. & WESHOFF, D. C. Microbiologia de los Alimentos. 4. ed. Zaragosa: Editorial Acribia, 2000. FREITAS, M. F. L.; PINHEIRO JUNIOR, J. W.; STAMFORD, T. L. M.; RABELO, S. S. A.; SILVA, D. R.; SILVEIRA FILHO, V. M.; SANTOS, F. G. B. & MOTA, R. A. Perfil de sensibilidade antimicrobiana in vitro de Staphylococcus coagulase positivos isolados de leite de vacas com mastite no agreste do Estado de Pernambuco. Arquivos do Instituto Biologico, S?o Paulo, v.72, n.2, p.171-177, 2005. Dispon?vel em: <http://www.biologico.sp.gov.br/ ARQUIVOS/V72_2/freitas.PDF>. Acesso em: 12 dez. 2011 FONSECA, L. F. L. & SANTOS, M. V. Qualidade do leite e controle de mastite. S?o Paulo : Lemos Editorial, 2000, 175p. FONTANA, V. L. D. S.; GIAMIMI, M. J. S. M.; LEITE, C.Q. F.; MIRANDA, E. T.; ALMEIDA, A. M. F.; FONTANA, C. A. P.; SOUZA, C. M. & STELLA, A. E. Etiologia da mastite bovina subcl?nica, sensibilidade dos agentes ?s grogas antimicrobianas e detec??o do agente da beta-lactamase e Staphylococcus aureus. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v. 17, n. 4, p. 552-559, 2010. FORBES, B.A.; SAHM, D.F. & WEISSFELD, A.S. Staphylococcus, Micrococcus and Similar Organisms. In: Bayiley & Scott?s Diagnostic Microbiology, 11 ed. Mosby: USA, 2002. FUDA, C.; FISHER, J. & MOBASHEREY, S. ?-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome. Cellular and Molecular Life Sciences (CMLS), v. 62, p. 2617-1633, 2005. GARCIA-?LVAREZ, L.; HOLDEN, M. T.; LINDSAY, H.; WEBB, C. R.; BROWN, D. F.; CURRAN, M. D.; WALPOLE, E.; BROOKS, K.; PICKARD, D. J.; TEALE, C.; PARKHILL, J.; BENTLEY, S. D.; EDWARDS, G. F.; GIRVAN, E K.; KEARNS, A. M.; PICHON, B.; HILL, R. L.; LARSEN, A. R.; SKOV, R. L.; PEACOCK, S. J.; MASKELL, D. J. & HOLMES, M. A. Methicillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: A descriptive study. Lancet Infectious Diseases, v. 11, n. 8, p. 595-603, 2011. GENTILINI, E.; DENAMIEL, G.; BETANCOR, A.; REBUELTO, M.; FERMEPIN, M.R. & DE TORREST, R. A. Antimicrobial susceptibility of coagulase negative staphylococci isolated from bovine mastitis in Argentina. American Dairy Science, v.85, p.1913-1917, 2002. GIANOLA, D.; HERINGSTAD, B.; KLEMETSDAL, G. & CHANG, Y. M. Longitudinal analysis of clinical mastitis at different stages of lactation in Norwegian cattle. Livestock Production Science, v. 88, p. 251-261, 2004. GOH, S. H.; POTTER, S.; WOOD, J. O.; HEMMINGSEN, S. M.; R EYNOLDS R. P. & CHOW, A. W. HSP60 gene Sequences as Universal Targets for Microbial Species 53 Identification: Studies with Coagulase-Negative Staphylococci. Journal of Clinical Microbiology, v. 34, n. 4, p. 818-823, 1996. GOLEMI-KOTRA, D.; CHA, J. Y.; MEROUEH, S. O.; VAKULENKO, S. B. & MOBASHERY, S. Resistance to b-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. Journal of Biological Chemistry, v. 278, p. 18419-18425, 2003. GODDEN, S. M.; JANSEN, J. T.; LESLIE, K. E. et al. The effect of sampling time and sample handling on the detection of Staphylococcus aureus in milk from quarters with subclinical mastitis. Canadian Veterinary Journal, v. 43, p. 38-42, 2002. GRAHAM, J. C. Comparison of PCR detection of mecA with methicillin and oxacillin disc susceptibility testing in coagulase-negative staphylococci. Journal of Antimicrobial Chemotherapy, v. 45, p. 111-113, 2000. GREGORY, P. D.; LEWIS, R. A.; CURNOCK, S. P. & DYKE, K. G. H. Studies of the repressor (BlaI) of ?-lactamase synthesis in Staphylococcus aureus. Molecular Microbiology. v. 24, p. 1025-1037, 1997. GUARDABASSI, L., S. SCHWARZ, AND D. H. LLOYD. Pet animals as reservoirs of antimicrobial-resistant bacteria. Journal of Antimicrobial and Chemotherapy, v. 54, p. 321?332, 2004. HACKBARTH, C. J. & CHAMBERS, H. F. blaI and blaR1 regulate beta-lactamase and PBP 2a production in methicillin-resistant Staphylococcus aureus. Antimicrobial Agents Chemotherapy, v. 37, n. 5, p. 1144-1149, 1993. HAGEMAN, J. C.; UYEKI, T. M.; FRANCIS, J. S.; JERNIGAN, D. B.; WHEELER, J. G.; BRIDGES, C. B.; BARENKAMP, S. J.; SIEVERT, D. M.; SRINIVASAN, A.; DOHERTY, M. C.; MCDOUGAL, L. K.; KILLGORE, G. E.; LOPATIN, U. A.; COFFMAN, R.; MCDONALD, J. K.; MCALLISTER, S. K.; FOSHEIM, G. E.; PATEL, J. B. & MCDONALD, L. C. Severe community-acquired pneumonia due to Staphylococcus aureus, 2003-04 influenza season. Emerging Infectious Diseases, v. 12, p. 894-899, 2006. HARDY, B. The issue of antibiotic use in the livestock industry: what have we learned? Animal Biotechnology, v. 13, n. 1, p. 129-147, 2002. HIRAMATSU, K.; HANAKI, H.; INO, T.; YABUTA, K.; OGURI, T. & TENOVER, F. C. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. Journal of Antimicrobial and Chemotherapy. v. 40, p. 135-136, 2001. HISATA, K.; KUWAHARA-ARAI, K.; YAMANOTO, M.; ITO, T.; NAKATOMI, Y.; CUI, L.; BABA, T.; TERASAWA, M.; SOTOZONO, C.; KINOSHITA, S.; YAMASHIRO, Y. & HIRAMATSU, K. Dissemination of methicillin-resistant staphylococci among healthy japanese children. Journal of Clinical Microbiology, v. 43, p. 3364-3372, 2005. HUDOME, S. M. & FISHER, M. C. Nosocomial infections in the neonatal intensive care. Current Opinion in Infectious Diseases, v. 14, p. 303-7, 2001. 54 HUXLEY, J. N.; GREENT, M. J.; GREEN, L. E. & BRADLEY, A. J. Evaluation of the efficacy of an internal teat sealer during the dry period. Journal of Dairy Science, v. 85, p. 551?561, 2002. ITO, T.; KATAYAMA, Y.; ASDA, K.; MORI, N.; TSUTSUMIMOTO, K.; TIENSASITORN, C.; & HIRAMATSU, K. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillinresistant S. aureus. Antimicrobial Agents and Chemotherapy, v. 45, p. 1323-1336, 2001. ITO, T.; OKUMA, K.; MA, X. X.; YUZAWA, H. & HIRAMATSU, K. Insights on antibiotics resistance of Staphylococcus aureus from its whole genome: genomic island SCC. Drug Resistance Updates, v. 6, n. 1, p. 41-52, fev. 2003. ITO, T.; MA, X. X.; TAKEUCHI, F.; OKUMA, K.; YUZAWA, H. & HIRAMATSU, K. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccr. Antimicrobial Agents and Chemotherapy, v. 48, p. 2637- 2651, 2004. JANSEN, M. D.; BOX, A. T. A. & FLUIT, A. C. SCCmec Typing in Methicillin-Resistant Staphylococcus aureus Strains of Animal Origin. Emerging Infectious Diseases, v. 15, n. 1, p. 136, 2009. JEVONS, M. P. ?Celbenin?- resistant staphylococci. British Medical Journal, v. 124, p. 124-125, jan. 1961. KARAHAN, M. AND CETINKAYA, B. Coagulase gene polymorphisms detected by PCR in Staphylococcus aureus isolated from subclinical bovine mastitis in Turkey. Veterinary Journal, v. 174, p. 428?431, 2006. KARAHAN, M. & CETINKA, Y. A. B. Coagulase gene polymorphisms detected by PCR in Staphylococcus aureus isolated from subclinical bovine mastitis in Turkey. Veterinary Journal, v. 174, n. 2, p. 428-431, 2007. KATAYAMA, Y.; ITO, T. & HIRAMATSU, K. Genetic organization of the chromosome region surrounding mecA in clinical staphylococcal strains: role of IS431-mediated mecI deletion in expression of resistance in mecA-carrrying, low-level methicillinresistant Staphylococcus haemolyticus. Antimicrobial Agents and Chemotherapy, v. 45, n. 7, p. 1955-1963, 2001. KLUYTMANS-VANDEN BERGH, M. F. Q. & KLUYTMANS, J. A. J. Communityacquired methicillin resistant Staphylococcus aureus: current perspectives. Clinical Microbiology Infectious, v. 12, n. 1, p, 9-15, 2006. KOHNER, J. P.; UHL, J.; KOLBERT, C.; PERSING, D. & COCKERILL, F. Comparison of susceptibility testing methods with mecA Gene analysis for determining oxacilin (methicilin) resistance in clinical isolates of Staphylococcus aureus and coagulase-negative staphylococcus spp. Journal of Clinical Microbiology, v. 37, n. 9, p.2952-2961, 1999. KONDO, Y.; ITO, T.; MA, X. X.; WATANABE, S.; KREISWIRTH, B. N.; ETIENNE, J. & HIRAMATSU, K. Combination of multiplex PCRs for staphylococcal cassette chromosome 55 mec type assignment: rapid identification system for mec, ccr and major differences in junkyard regions. Antimicrobial Agents and Chemotherapy, v. 51, p. 264-74, 2007. KONEMAN, E. W.; ALLEN, S. D.; JANDA, W. M; SCHRECKENBERGER, P. C. & WINN, J.R. Diagn?stico Microbiol?gico, 6.ed. Rio de Janeiro: Editora MEDS, 1488p, 2008. KURODA, M.; OHTA, T.; UCHIYAMA, I.; BABA T.; YUZAWA, H. I.; KOBAYASHI, L.; CUI, A.; OGUCHI, K.; AOKI, Y. & NAGAI, J. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. New Englang Journal Medicine, v. 319, p.157-61, 2001. LANGONI, H.; MENDON?A, A. O. & DEVELLEY, A. Avalia??o do uso da associa??o da bromexina com gentamicina no tratamento da mastite subcl?nica bovina. Revista Napgama, n. 1, p. 4-7, 2000. LEITER, T.(2000) Cephalosporins. http://www.fhsu.edu/nursing/otitis/cephalosporins.html Acessado em dezembro de 2011 LENCASTRE, H. & OLIVEIRA, D. C. Multiplex PCR Strategy for Rapid Identification of Structural Types and Variants of the mec Element in Methicillin-Resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, v. 46, n. 7, p. 2155?2161, 2002. LEWIS, R. A.; CURNOCK, S. C. & DYKE, K. G. H. Proteolytic cleavage of the repressor (BlaI) of ?-lactamase synthesis in Staphylococcus aureus. FEMS Microbiology Letters. v. 178, p. 271-275, 1999. LEWIS, R. A. & DIKE, K. G. H. mecI repress synthesis from the ??lactmase operon of Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, v. 5, p.139-144, 2005. LI, X. Z.; MEHROTRA, M.; GHIMIRE, S. & ADEWOYE, L. ?-Lactam resistance and ?- lactamases in bacteria of animal origin . Veterinary Microbiology, v. 121, p.197-214, 2007. LILENBAUM, W.; VERAS, M.; BLUM, E. & SOUZA, G.N. Antimicrobial susceptibility of staphylococci isolated from otitis externa in dogs. Letters of Applied Microbiology, v. 31, p. 42-45, 2000. LOWY, F.D. Antimicrobial resistence: the example of Staphylococcus aureus. Journal of Clinical Investigation, v. 111, n. 9, p. 1265-1273, mai. 2003. LI, X. Z. AND NIKAIDO, H. Efflux-mediated drug resistance in bacteria. Drugs, v. 64, p. 159-204, 2004. LIM, J. A.; KWON, A. R.; KIM, S. K.; CHOMG, Y.; LEE, K. & CHOI, E.C. Prevalence of resitance to macrolide, lincosamide and streptrogramine antibiotics in Gram-positive cocci isolated in Koream hospital. Journal of Antimicrobial Chemotheraty, v. 49, p.489-495, 2002. LUDWIG, W.; SCHLEIFER, K-H. & WHITMAN, W. B.. Revised Road Map to the Phylum Firmicutes. http://www.bergeys.org/outlines/Bergeys_Vol_3_Outline.pdf, p. 1-32, 2009. 56 MA, X. X.; ITO, T.; TIASANSITORN, C.; JAMKLANG, M.; CHONGTRAKOOL, P.; BOYLE-VAVRA, S.; DAUM, R. S. & HIRAMATSU, K. Novel type of staphylococcal cassette chromosome mec identifield in community-acquired methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemotherapy, v. 46, n. 4, p. 1147-52, 2002. MACHADO, T.R.O.; CORREA, M.G. & MARINS, J.M. Antimicrobial susceptibility of coagulase-negative Staphylococci isolated from mastitic cattle in Brazil. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v. 60, n. 1, p. 278-282, 2008. MARINHO, M.; BALDINE, S.; SILVA, A. V.; LISTONI, F. J. P. & LANGONI, H. A??o in vitro da enrofloxacina em microganismos isolados de leite mast?tico da regi?o de Botucatu- SP. / The in vitro action of enrofloxacin on the microrganisms isolated from mastitic bovine milk. Ars Veterinaria, Jaboticabal, SP, v. 18, n. 2, p. 120-124, 2002. MARTINS, R. P.; MARQUES, M. R. H. & NETO, A .C. Etiologia da mastite subcl?nica em vacas do rebanho de uma queijaria em Nossa Senhora do Livramento, MT. Revista Higiene Alimentar, S?o Paulo, v. 20, n. 13, p. 104-110, 2006. MCKINNEY, T. K.; SHARMA, V. K.; CRAIG, W. A. & ARCHER, G. L. Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and ?-lactamase regulators. Journal Bacteriology, v. 183, n. 23, p. 6862-8, 2001. MOON, J. S.; LEE, A. R.; KANG, H. M.; LEE, E. S.; KIM, M. N.; PAIK, Y. H.; PARK, Y. H.; JOO, Y. S. & KOO, H. S. Phenotypic and Genetic Antibiogram of Methicillin-Resistant Staphylococci Isolated from Bovine Mastitis in Korea. Journal of Dairy Science, v. 90, p.1176-1185, 2007. MORONI, P.; PISONI, G.; ANTONINI, M.; VILLA, R.; BOETTHCER, P. & CARLI, S. Antimicrobial drug susceptibility of Staphylococcus aureus from subclinical bovine masitis en Italy. Journal of Dairy Science, v. 89, p. 2973-2976, 2006. MORSE, S.I. Estafilococos. In: Braude AI, Davis CE, Fierer J, editors. Microbiologia Cl?nica. Buenos Aires: Panamericana, p. 313-20, 1984. MURAKAMI, K. W.; MINAMIDE, K.; WADA, W.; NAKAMURA, E.; TERAOKA, H. & WATANBE, S. Identification of methicillin resistant strains of staphylococci by polymerase chain reaction. Journal of Clinical Microbiology, v. 29, p.2240-2244, 1991. NADER FILHO, A.; SCHOCKEN-ITURRINO, R. P.; ROSSI JUNIOR, O. D. & AMARAL, L. A. Sensibilidade dos Staphylococcus aureus isolados em casos de mastite bovina, ? a??o de antibi?ticos e quimioter?picos. Arquivo Brasileiro de Medicina Veterin?ria e Zootecnia, v. 38, n. 4, p. 581-588, 2000. NADER FILHO, A.; FERREIRA, L. M.; AMARAL, L. A.; ROSSI J?NIOR, O. D. & OLIVEIRA, R. P. Sensibilidade antimicrobiana de Sthaphylococcus aureus isolados no leite de vacas com mastite. Arquivos do Instituto Biol?gico, S?o Paulo, v. 74, n. 1, p.1-4, 2007. 57 NATIONAL CENTER FOR BIOTECHNOLOGY INFORMATION. TaxBrowser, Washington, 12 dez. 2006. Dispon?vel em: http://www.ncbi.nlm.nih.gov/sites/entrez?db=taxonomy. Acesso em: 10 dez. 2011. NEVES, M. C.; ROSSI, O. D. J.; ALVES, E. C. C. & LEMOS, M. V. F. Detec??o de genes de resist?ncia antimicrobiana em cromossomos e plasm?deos de Staphylococcus spp. Arquivo do Instituto de Biologia de S?o Paulo, v. 74, n. 3, p. 207-213, 2007. NUNES, M. T. & D`ANGELINO, J. L. Ocorr?ncia de res?duos de antibi?ticos no leite, em fazendas produtoras e no leite pronto para consumo. Revista Higiene Alimentar, v. 21, p. 57-61, 2007. OLIVEIRA, D. C.; MILHEIRI?O, C.; & DE LENCASTRE, H. Redefining a structural variant of staphylococcal cassette chromosome mec, SCCmec type VI. Antimicrobial Agents and Chemotherapy, v. 50, p.3457-3459, 2006. OLIVEIRA, C. M. C.; SOUSA, M. G. S.; SILVA, N. S.; MENDON?A, C. L.; SILVEIRA, J. A. S.; OAIGEN, R. P.; ANDRADE, S. J. T. & BARBOSA, J. D. Preval?ncia e etiologia da mastite bovina na bacia leiteira de Rondon do Par?, estado do Par?. Pesquisa Veterin?ria Braileira, v. 31, n. 2, p. 104-110, 2011. (a) OLIVEIRA, J. M. B.; VANDERLEI, D. R.; BRANDESPIM, D. F.; MOTA, R. A.; J?NIOR, J. W. P. An?lise do perfil de sensibilidade antimicrobiana de staphylococcus spp. isolados de vacas com mastite subcl?nica do agreste do Estado de Pernambuco. Vet. e Zootec. 18(4 Supl. 3): IX Congresso Brasileiro Buiatria. 04 a 07 de Outubro de 2011. Goi?nia - Goi?s, Brasil, 2011. (b) PALAZZO, I.C. & DARINI, A.L. Evaluation of methods for detecting oxacillin resistance in coagulase-negative staphylococci including cefoxitin disc difusion. Microbiology Letters, v. 257, p. 299?305, 2006. PALMA M,; HAGGAR A. & FLOCK J. Adherence of Staphylococcus aureus is enhanced by an endogenous secreted protein with broad binding activity. Journal of Bacteriology,v. 181, p. 2840?2845, 1999. PEREIRA, I.A.; SOARES, L.C.; COELHO, S.M.O.; PRIBUL, B.R. & SOUZA, M.M.S. Suscetibilidade ? azitromicina de isolados bacterianos de processos infecciosos em c?es e gatos. Pesquisa Veterin?ria Brasileira, v. 29, n. 2, p.153-159, 2009. PEDERSEN, L. H.; AALBAEK, B.; RONTVED, C. M.; INGVARTSEN, K. L.; SORENSEN, N. S.; HEEGAARD, P. M. & JENSEN, H. E. Early pathogenesis and inflammatory response in experimental bovine mastitis due to Streptococcus uberis. Journal of Comparative Pathology, v. 128, p. 156- 164. 2003. PEREIRA, I. A. Processos infecciosos de animais de companhia: uma abordagem sobre fatores de virul?ncia em Staphylococcus spp. e resist?ncia ? azitromicina e oxacilina como modelo de estudo. 166 p. Tese (Doutorado em Ci?ncias Veterin?rias). Instituto de Veterin?ria, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Serop?dica, RJ, 2010. 58 PERSSON WALLER, K.; COLDITZ, I.G.; LUN, S. & OSTENSSON, K. Cytokines in mammary lymph and milk during endotoxininduced bovine mastitis. Research in Veterinary Science, v. 75, p. 247-155, 2003. PETINAKI, E.; ARVANITI, A.; DIMITRACOPOULOS, G. & SPILIOPOULOU, I.; Detection of mecA, mecR1 and mecI genes among clinical isolates of methicilin-resistant staphylococci by combined polymerase chain reactions. Journal of Antimicrobial Chemotherapy, v. 47, p.297-304, 2001. PINHEIRO DE S?, M. E.; CUNHA, M. L. R. S.; ELIAS, A. O.; CASSIANO, V. & LANGONI, H. Import?ncia do Staphylococcus aureus nas mastites subcl?nicas: pesquisa de enterotoxinas e toxina do choque t?xico, e a rela??o com a contagem de c?lulas som?ticas. Brazilian Journal of Veterinary Research and Animal Science, v. 41, p. 320-326, 2004. PITK?L?, A.; HAVERI, M.; PY?R?L?, S.; MYLLYS, V. & HONKANEN-BUZALSKI, T. Bovine mastitis in Finland 2001: prevalence, distribution of bacteria, and antimicrobial resistance. Journal of Dairy Science, v. 87, p. 2433-2441, 2004. PYORALA, S. & TAPONEN, S. Coagulase-negative staphylococci: Emerging mastitis pathogens. Veterinary Microbiology, v. 134, p. 3-8, 2009. RADOSTITS, O. M.; Blood, D. C. & Gay, C. C. Cl?nica Veterin?ria. Um tratado de doen?as dos bovinos, ovinos, su?nos, caprinos e eq?inos. 9 ed. Rio de Janeiro: Guanabara Koogan. 1737 p, 2002. REINOSO, E. B.; EL-SAYED, A.; L?MMLER, C.; BOGNI, C. & ZSCH?CK M. Genotyping of Staphylococcus aureus isolated from humans, bovine subclinical mastitis and food samples in Argentina. Microbiological Research., v. 163, p. 314-22, 2006. REIS, A.; CORDEIRO, J. C. R.; MACHADO, A. M. O. & SADDER, H. S. In vitro antimicrobial activity of linezolid tested against vancomycin-resistant enterococci isolated in Brazilian hospitals. Brazilian Journal of Infectious Diseases, v. 5, n. 5, p. 243-51, Bras?lia, 2001. REIS, S. R.; SILVA, N. & BRESCIA, M. V. Antibioticoterapia para controle da mastite subcl?nica d |
Page generated in 0.0078 seconds