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Protein expression and antifungal effect of fluconazole-resistant Candida species following effective in vitro treatment with K21, a novel antifungal agent

Philosophiae Doctor - PhD / Background: Oropharyngeal candidiasis, caused by the fungus Candida, is the most common
opportunistic infection affecting the quality of life of immunocompromised patients. Fluconazole
is widely used as the first line of treatment for fungal infections. However, the inappropriate and
misguided use of the drug has led to the evolvement of fluconazole-resistant Candida organisms.
This arising resistance resulted in the urgent need for the development of new antimicrobial
drugs. The aim of the present study was to investigate the antifungal action of K21, a novel
antimicrobial quarternary ammonium compound, on fluconazole-resistant Candida species.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/7889
Date January 2019
CreatorsJohn, Cathy Nisha
ContributorsAfrica, Charlene WJ
PublisherUniversity of Western Cape
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
RightsUniversity of Western Cape

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