Background: To investigate whether vaccination against SARS-CoV-2 is associated with
the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data
from patients with central and branch retinal vein occlusion (CRVO and BRVO), central and branch
retinal artery occlusion (CRAO and BRAO), and anterior ischaemic optic neuropathy (AION) were
retrospectively collected during a 2-month index period (1 June–31 July 2021) according to a defined
protocol. The relation to any previous vaccination was documented for the consecutive case series.
Numbers of RVOD and COVID-19 vaccination were investigated in a case-by-case analysis. A case–
control study using age- and sex-matched controls from the general population (study participants
from the Gutenberg Health Study) and an adjusted conditional logistic regression analysis was
conducted. Results: Four hundred and twenty-one subjects presenting during the index period
(61 days) were enrolled: one hundred and twenty-one patients with CRVO, seventy-five with BRVO,
fifty-six with CRAO, sixty-five with BRAO, and one hundred and four with AION. Three hundred
and thirty-two (78.9%) patients had been vaccinated before the onset of RVOD. The vaccines given
were BNT162b2/BioNTech/Pfizer (n = 221), followed by ChadOx1/AstraZeneca (n = 57), mRNA-
1273/Moderna (n = 21), and Ad26.COV2.S/Johnson & Johnson (n = 11; unknown n = 22). Our
case–control analysis integrating population-based data from the GHS yielded no evidence of an
increased risk after COVID-19 vaccination (OR = 0.93; 95% CI: 0.60–1.45, p = 0.75) in connection with
a vaccination within a 4-week window. Conclusions: To date, there has been no evidence of any
association between SARS-CoV-2 vaccination and a higher RVOD risk.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:89594 |
| Date | 07 February 2024 |
| Creators | Feltgen, Nicolas, Ach, Thomas, Ziemssen, Focke, Quante, Carolin Sophie, Gross, Oliver, Din Abdin, Alaa, Aisenbrey, Sabine, Bartram, Martin C., Blum, Marcus, Brockmann, Claudia, Dithmar, Stefan, Friedrichs, Wilko, Guthoff, Rainer, Hattenbach, Lars-Olof, Herrlinger, Klaus R., Kaskel-Paul, Susanne, Khoramnia, Ramin, Klaas, Julian E., Krohne, Tim U., Lommatzsch, Albrecht, Lueken, Sabine, Maier, Mathias, Nassri, Lina, Nguyen-Dang, Thien A., Radeck, Viola, Rau, Saskia, Roider, Johann, Sandner, Dirk, Schmalenberger, Laura, Schmidtmann, Irene, Schubert, Florian, Siegel, Helena, Spitzer, Martin S., Stahl, Andreas, Stingl, Julia V., Treumer, Felix, Viestenz, Arne, Wachtlin, Joachim, Wolf, Armin, Zimmermann, Julian, Schargus, Marc, Schuster, Alexander K. |
| Publisher | MDPI |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 5101 |
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