Background: Lifestyle and environmental factors are known to contribute to allergic
disease development, especially very early in life. However, the link between diet
composition and allergic outcomes remains unclear.
Methods: In the present population-based cohort study we evaluated the dietary
intake of 10-year-old children and analyses were performed with particular focus
on atopic dermatitis or food allergy, allergic diseases known to be affected
by dietary allergens. Dietary intake was assessed via semi-quantitative food
frequency questionnaires. Based on these data, individual nutrient intake as well as
children’s Dietary Inflammatory Index (C-DIITM) scores were calculated. Information
about atopic manifestations during the first 10 years of life and confounding
factors were obtained from standardized questionnaires during pregnancy and
annually thereafter.
Results: Analyses from confounder-adjusted logistic regression models (n = 211)
revealed that having atopic outcomes was associated with having a pro-inflammatory
pattern at the age of 10 years: OR = 2.22 (95% CI: 1.14–4.31) for children with atopic
dermatitis and OR = 3.82 (95% CI: 1.47–9.93) for children with food allergy in the first
10 years of life
Conclusion: A pro-inflammatory dietary pattern might worsen the atopic outcome and
reduce the buffering capacity of the individual against harmful environmental exposures
or triggers. For pediatricians it is recommended to test for the individual tolerance of
allergenic foods and to increase the nutrient density of tolerable food items to avoid
undesirable effects of eating a pro-inflammatory diet.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:85843 |
| Date | 07 June 2023 |
| Creators | Schütte, Olivia, Bachmann, Larissa, Shivappa, Nitin, Hebert, James R., Felix, Janine F., Röder, Stefan, Sack, Ulrich, Borte, Michael, Kiess, Wieland, Zenclussen, Ana C., Stangl, Gabriele I., Herberth, Gunda, Junge, Kristin M. |
| Publisher | Frontiers Media S.A. |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 868872 |
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